Department of Morphology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
JBRA Assist Reprod. 2021 Feb 2;25(1):136-149. doi: 10.5935/1518-0557.20200051.
This integrative review evaluated the most commonly diagnosed causes of infertility in men and women in Brazil, as well as the medically assisted reproduction technologies regularly employed in these cases. We searched in four electronic databases (PubMed, including Medline; Scopus; Web of Science and LILACS), and two grey literature (Google Scholar and OpenGrey), guided by the focused question: "What are the main factors responsible for male and female infertility in Brazil, and what are its relationships with success rates after assisted reproduction treatment?". We included interventional or observational studies, without limitation by language or year of publication. Our searches in the electronic indexers recovered 1,119 articles, and after analyzing the inclusion and exclusion criteria, 27 articles composed the body of analysis for this review. We grouped the studies into four themes: factors responsible for male and female infertility, assisted reproductive technologies (ART) used in the infertility treatment, assisted reproduction procedures, and clinical predictors of success rates in ART. Despite the scarcity of studies analyzing the association between infertility and assisted reproductive technologies in Brazil, it was possible to infer that the most prevalent infertility cause in women was endometriosis, while in men it was azoospermia. The most widely assisted reproductive technology applied in the country is the intracytoplasmic injection of spermatozoa (ICSI), ensuring better success rates in the treatment of infertility for men and women.
这篇综合评价评估了巴西男女不孕不育最常见的病因，以及这些情况下常采用的医学辅助生殖技术。我们在四个电子数据库（PubMed，包括 Medline；Scopus；Web of Science 和 LILACS）以及两个灰色文献（Google Scholar 和 OpenGrey）中进行了检索，检索问题是：“巴西男女不孕不育的主要原因是什么，以及它与辅助生殖治疗后的成功率有什么关系？”。我们纳入了干预性或观察性研究，不受语言或发表年份的限制。我们在电子索引中的检索共检索到 1119 篇文章，经过纳入和排除标准的分析，27 篇文章构成了本次综述的分析主体。我们将这些研究分为四个主题：男女不孕不育的原因、不孕不育治疗中使用的辅助生殖技术 (ART)、辅助生殖程序以及 ART 成功率的临床预测因素。尽管巴西对不孕不育与辅助生殖技术之间的关联进行分析的研究较少，但可以推断出女性不孕最常见的原因是子宫内膜异位症，而男性不孕最常见的原因是无精症。在该国应用最广泛的辅助生殖技术是精子胞浆内注射（ICSI），它能提高男性和女性不孕不育治疗的成功率。
