Tilly H, Bastard C, Halkin E, Lenormand B, Bizet M, Dauce J P, Lees O, Monconduit M, Piguet H
Centre Henri Becquerel, Rouen, France.
Am J Clin Pathol. 1988 Jan;89(1):109-13. doi: 10.1093/ajcp/89.1.109.
Some recurrent chromosomal abnormalities have recently been found to be associated with distinctive histologic subtypes of non-Hodgkin's lymphoma (NHL). In a study of 62 patients with NHL whose karyotypes was determined at diagnosis, 3 patients were found to have a deletion of the long arm of chromosomes 14 at band 22 (del[14][q22]). All had a diffuse lymphoma with generalized lymphadenopathy and bone marrow involvement. All three lymphomas were of B-cell origin, as shown by the presence of surface immunoglobulin and monoclonal antibody phenotyping. For each patient, a trisomy 12 was associated with del(14)(q22) in a clone. These data suggest that del(14)(q22), perhaps in association with trisomy 12, could identify a subtype of NHL and that band 22 of chromosome 14 may be implicated in the B-cell ontogeny.
最近发现一些复发性染色体异常与非霍奇金淋巴瘤（NHL）的独特组织学亚型相关。在一项对62例NHL患者的研究中，这些患者在诊断时进行了核型测定，发现3例患者存在14号染色体长臂22带缺失（del[14][q22]）。所有患者均患有弥漫性淋巴瘤，伴有全身淋巴结肿大和骨髓受累。如表面免疫球蛋白和单克隆抗体表型所示，所有这三种淋巴瘤均起源于B细胞。对于每位患者，在一个克隆中，12号三体与del(14)(q22)相关。这些数据表明，del(14)(q22)，可能与12号三体相关，可识别出一种NHL亚型，并且14号染色体的22带可能与B细胞个体发育有关。
