Ashton A, Alexander D P, DeBellis C, Schumann G B
Department of Pathology, College of Medicine, University of Utah Medical Center, Salt Lake City 84132.
Am J Clin Pathol. 1988 Jan;89(1):113-7. doi: 10.1093/ajcp/89.1.113.
Five hundred eighty-seven daily urine specimens were examined from 179 consecutive renal allograft recipients with the use of quantitative cytodiagnostic urinalysis. Specimens were divided between those patients receiving cyclosporine (CyA) and steroid immunotherapy (73 patients) and those receiving standard azathioprine (Aza) and steroid immunotherapy (106 patients). When patients with urinary tract infections were excluded, an increase in leukocyturia was observed in the CyA-treated patients. Ninety-three percent of the CyA-treated patients had at least one specimen with more than 1,000 neutrophils/10 high-power fields (HPFs) versus 62% of the 106 Aza-treated patients. Sixty-four percent of the specimens examined from the CyA-treated group had more than 1,000 neutrophils/10 HPFs compared with only 18% of specimens from Aza-treated patients. It appears that CyA is a cause of sterile leukocyturia in renal allograft recipients. The significance of leukocyturia in CyA nephrotoxicity needs further definition.
采用定量细胞诊断尿液分析方法，对179例连续的肾移植受者的587份日常尿液标本进行了检查。标本分为接受环孢素（CyA）和类固醇免疫治疗的患者（73例）以及接受标准硫唑嘌呤（Aza）和类固醇免疫治疗的患者（106例）。排除尿路感染患者后，观察到接受CyA治疗的患者白细胞尿增加。接受CyA治疗的患者中，93%至少有一份标本的中性粒细胞超过1000/10高倍视野（HPF），而接受Aza治疗的106例患者中这一比例为62%。CyA治疗组检查的标本中有64%的中性粒细胞超过1000/10 HPF，而Aza治疗患者的标本中这一比例仅为18%。看来CyA是肾移植受者无菌性白细胞尿的一个原因。白细胞尿在CyA肾毒性中的意义需要进一步明确。
