Department of Internal Medicine, Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, 213 Borowska St., 50-556, Wroclaw, Poland.
Department of Hygiene, Wroclaw Medical University, 7 Mikulicza-Radeckiego St., 50-345, Wroclaw, Poland.
Sleep Breath. 2021 Jun;25(2):669-675. doi: 10.1007/s11325-020-02157-3. Epub 2020 Aug 6.
Renalase plays an important role in blood pressure regulation. Obstructive sleep apnea (OSA) is a common respiratory disorder associated with hypertension and cardiovascular complications. The aim of the study was to assess the relationship between sleep apnea and renalase concentration.
Adult patients (n = 113) were evaluated for OSA in a sleep laboratory using polysomnography. The respiratory events were scored according to the standards developed by the American Academy of Sleep Medicine. The blood renalase concentration was determined by the ELISA (enzyme-linked immunosorbent assay) test.
OSA (AHI ≥ 5) was diagnosed in 71% (n = 80) of the studied population. Renalase concentration was statistically significantly lower in the group with moderate-to-severe OSA (AHI ≥ 15) compared with the group without OSA (AHI < 5) (139.56 ± 175.72 ng/ml vs. 230.97 ± 240.50 ng/ml, p = 0.042). We have found statistically significant negative correlation between renalase and AHI in hypertensives, but not in normotensives. The statistically significant negative correlation was observed between AHI and renalase in the whole studied group, in males, and in the group of age < 60 years old. There was not such a correlation in females and in the group > 60 years old. Based on the regression model, it was shown that lower renalase concentration, hypertension, higher BMI, and male gender are independently associated with higher AHI.
There is a relationship between the blood renalase concentration and the severity of OSA, which may influence hypertension development in OSA.
肾酶在血压调节中起着重要作用。阻塞性睡眠呼吸暂停（OSA）是一种常见的与高血压和心血管并发症相关的呼吸障碍。本研究旨在评估睡眠呼吸暂停与肾酶浓度之间的关系。
对 113 名成年患者在睡眠实验室进行多导睡眠图检查以评估 OSA。根据美国睡眠医学学会制定的标准对呼吸事件进行评分。通过 ELISA（酶联免疫吸附测定）试验测定血液肾酶浓度。
在所研究的人群中，71%（n=80）诊断为 OSA（AHI≥5）。与无 OSA 组（AHI<5）相比，中重度 OSA 组（AHI≥15）的肾酶浓度明显降低（139.56±175.72 ng/ml 与 230.97±240.50 ng/ml，p=0.042）。我们发现肾酶与高血压患者的 AHI 之间存在显著的负相关，但在血压正常者中则无此相关性。在整个研究组、男性和年龄<60 岁的患者中，均观察到 AHI 与肾酶之间存在显著的负相关。但在女性和年龄>60 岁的患者中则没有这种相关性。基于回归模型，结果表明，较低的肾酶浓度、高血压、更高的 BMI 和男性性别与更高的 AHI 独立相关。
血液肾酶浓度与 OSA 的严重程度之间存在关系，这可能影响 OSA 患者的高血压发展。
