Center for AIE Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, China.
Key Laboratory of Optoelectronic Devices and Systems, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China.
Adv Mater. 2020 Sep;32(37):e2003382. doi: 10.1002/adma.202003382. Epub 2020 Aug 6.
Inspired by the respective advantages of aggregation-induced emission (AIE)-active photosensitizers and black phosphorus nanomaterials in cancer treatment, the facile construction of novel AIE photosensitizers married to 2D black phosphorus nanosheets and their application for multimodal theranostics are demonstrated. The developed nanomaterial simultaneously possesses distinctive properties and multiple functions including excellent stability, good biocompatibility, intensive fluorescence emission in the NIR region, high-performance reactive oxygen species generation, good photothermal conversion efficiency, outstanding cellular uptake, and effective accumulation at the tumor site. Both in vitro and in vivo evaluation show that the presented nanotheranostic system is an excellent candidate for NIR fluorescence-photothermal dual imaging-guided synergistic photodynamic-photothermal therapies. This study thus not only extends the applications scope of AIE and black phosphorus materials, but also offers useful insights into designing a new generation of cancer theranostic protocol for potential clinical applications.
受聚集诱导发光（AIE）活性光敏剂和黑磷纳米材料在癌症治疗方面各自优势的启发，本研究构建了一种新型 AIE 光敏剂与二维黑磷纳米片结合的方法，并将其用于多模式治疗学。所开发的纳米材料同时具有独特的性质和多种功能，包括优异的稳定性、良好的生物相容性、在近红外区域强烈的荧光发射、高效的活性氧生成、良好的光热转换效率、出色的细胞摄取能力以及在肿瘤部位的有效积累。体外和体内评价均表明，所提出的纳米治疗系统是一种用于近红外荧光-光热双模式成像引导协同光动力-光热治疗的优秀候选物。因此，本研究不仅扩展了 AIE 和黑磷材料的应用范围，还为设计新一代癌症治疗学方案提供了有益的见解，以满足潜在的临床应用需求。
