银屑病关节炎：非 HLA 遗传研究与重要信号通路的系统综述。

Psoriatic arthritis: A systematic review of non-HLA genetic studies and important signaling pathways.

机构信息

Department of Dermatology, Anhui Provincial Corps Hospital of Chinese People's Armed Police Forces, Hefei, China.

Institute of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China.

出版信息

Int J Rheum Dis. 2020 Oct;23(10):1288-1296. doi: 10.1111/1756-185X.13879. Epub 2020 Aug 6.

DOI:10.1111/1756-185X.13879

PMID:32761870

Abstract

Psoriatic arthritis (PsA) is a common, chronic inflammatory disease with complex pathogenesis. In recent years, a number of susceptibility non-human leukocyte antigen (HLA) genes of PsA have been revealed, which also act as important factors in the pathogenesis of PsA as well as HLA genes. By searching the databases National Center for Biotechnology Information, Google and PubMed, 37 articles are included and 50 susceptibility non-HLA genes for PsA are presented, such as IL23A, TNIP1, TYK2, STAT4, IL12B, RUNX3 and TRAF3IP2. In these non-HLA genes, some are common genes shared with other diseases, whereas most of these susceptibility genes are related to the pathogenesis of PsA by activation or inhibition of the signaling pathways. Several signaling pathways possibly implicated in the pathogenesis of PsA are introduced in this paper, including the 2 mainly signaling pathways, IL23/Th17 signaling pathway and NF-κB signaling pathway, and the other involved signaling pathways, such as JAK-STAT signaling pathway and MAPK signaling pathway.

摘要

银屑病关节炎（PsA）是一种常见的慢性炎症性疾病，其发病机制复杂。近年来，已经揭示了许多银屑病关节炎的易感非人类白细胞抗原（HLA）基因，这些基因也作为 HLA 基因以外的重要因素在银屑病关节炎的发病机制中发挥作用。通过在国立生物技术信息中心、谷歌和 PubMed 数据库中进行搜索，共纳入 37 篇文章，介绍了 50 个银屑病关节炎的易感非 HLA 基因，如 IL23A、TNIP1、TYK2、STAT4、IL12B、RUNX3 和 TRAF3IP2。在这些非 HLA 基因中，有些是与其他疾病共同的常见基因，而大多数这些易感基因通过激活或抑制信号通路与银屑病关节炎的发病机制有关。本文介绍了几种可能与银屑病关节炎发病机制有关的信号通路，包括 2 个主要的信号通路，IL23/Th17 信号通路和 NF-κB 信号通路，以及其他涉及的信号通路，如 JAK-STAT 信号通路和 MAPK 信号通路。