Department of Life, Health and Environmental Sciences (MESVA), University of LAquila, LAquila, Italy.
J Biol Regul Homeost Agents. 2013 Jul-Sep;27(3):909-12.
Psoriatic arthritis (PsA) is described as a multifactorial autoimmune rheumatic disease although its development is surely linked to some specific HLA genes (especially the HLA-Cw*06:02 allele). To date, its complex immunopathogenetic mechanism is not well clarified. Actually, increasing evidence suggest that qualitative and quantitative interplays between some PsA-susceptibility HLA alleles and other genetic, regulatory and environmental factors, may develop distinct subphenotypes of PsA. We first provide a brief summary of current knowledge about the various PsA conditions. Then, we consider the reasons why further analysis of the clinical course of patients affected by distinct PsA subsets, and who receive different therapeutic treatments, should be carried out in conjunction with deeper investigations about the identification of key genes and immunoregulatory agents by applying the most recent advances in biotechnology. This approach could better explain the molecular mechanisms responsible for both the onset and progression of this multi-faceted pathology with the purpose of significantly improving the management of PsA patients.
银屑病关节炎（PsA）被描述为一种多因素自身免疫性风湿病，尽管其发病肯定与某些特定的 HLA 基因（尤其是 HLA-Cw*06:02 等位基因）有关。迄今为止，其复杂的免疫发病机制尚不清楚。实际上，越来越多的证据表明，一些 PsA 易感性 HLA 等位基因与其他遗传、调节和环境因素之间的定性和定量相互作用，可能会发展出不同的 PsA 亚表型。我们首先简要总结了目前对各种 PsA 情况的认识。然后，我们考虑了为什么应该对受不同 PsA 亚群影响的患者的临床病程进行进一步分析，以及为什么应该结合对关键基因和免疫调节因子的鉴定进行更深入的研究，应用生物技术的最新进展。这种方法可以更好地解释导致这种多方面病理发生和进展的分子机制，目的是显著改善 PsA 患者的管理。
