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Analysis of genetic alterations identifies the frequent mutation of GNAS in colorectal laterally spreading tumors.

作者信息

Nong Yanying, Zhang Yuru, Zhang Yi, Pan Lei, Chen Junsheng, Zhu Chaojun, Han Lu, Li Aimin, Liu Side

机构信息

Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, P. R. China.

出版信息

Cancer Commun (Lond). 2020 Nov;40(11):636-640. doi: 10.1002/cac2.12085. Epub 2020 Aug 6.

DOI:10.1002/cac2.12085
PMID:32762003
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7668477/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4c6/7668477/c7980e3b6850/CAC2-40-636-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4c6/7668477/229865bde730/CAC2-40-636-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4c6/7668477/c7980e3b6850/CAC2-40-636-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4c6/7668477/229865bde730/CAC2-40-636-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4c6/7668477/c7980e3b6850/CAC2-40-636-g002.jpg

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Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.全球癌症统计数据 2018：GLOBOCAN 对全球 185 个国家/地区 36 种癌症的发病率和死亡率的估计。
CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epub 2018 Sep 12.
2
Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors.整合基因、表观遗传和转录分析确定侧向扩散肿瘤发生发展中的分子通路。
Mol Cancer Res. 2016 Dec;14(12):1217-1228. doi: 10.1158/1541-7786.MCR-16-0175. Epub 2016 Sep 26.
3
GNAS Spectrum of Disorders.
GNAS相关疾病谱
Curr Osteoporos Rep. 2015 Jun;13(3):146-58. doi: 10.1007/s11914-015-0268-x.
4
Long-term risk of colorectal cancer in individuals with serrated polyps.锯齿状息肉患者的结直肠癌长期风险。
Gut. 2015 Jun;64(6):929-36. doi: 10.1136/gutjnl-2014-307793. Epub 2014 Nov 16.
5
Clinicopathological characteristics of laterally spreading colorectal tumor.大肠侧向发育型肿瘤的临床病理特征
PLoS One. 2014 Apr 21;9(4):e94552. doi: 10.1371/journal.pone.0094552. eCollection 2014.
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Signatures of mutational processes in human cancer.人类癌症中的突变过程特征。
Nature. 2013 Aug 22;500(7463):415-21. doi: 10.1038/nature12477. Epub 2013 Aug 14.
7
Mutational heterogeneity in cancer and the search for new cancer-associated genes.癌症中的突变异质性与新的癌症相关基因的寻找。
Nature. 2013 Jul 11;499(7457):214-218. doi: 10.1038/nature12213. Epub 2013 Jun 16.
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Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples.检测不纯和异质癌症样本中的体细胞点突变。
Nat Biotechnol. 2013 Mar;31(3):213-9. doi: 10.1038/nbt.2514. Epub 2013 Feb 10.
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Comprehensive molecular characterization of human colon and rectal cancer.全面的人类结肠和直肠癌分子特征分析。
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