Rodenburg C J, Koelma I A, Nap M, Fleuren G J
Department of Pathology, Leiden University Hospital, The Netherlands.
Arch Pathol Lab Med. 1988 Feb;112(2):151-4.
The monoclonal antibody RAP 5 immunoreactive with the ras gene product p21 was used in an immunohistochemical study of 57 patients with advanced ovarian cancer and in 28 normal ovaries. The pattern of the staining of various tumor specimens was similar to the germinal epithelium of normal ovaries, whereas the intensity of staining was more enhanced in carcinomas than in normal ovaries. However, we found a lack of correlation among staining intensity of RAP 5 and the histologic type, the histologic grade, the ploidy class, and the clinical outcome.
与ras基因产物p21发生免疫反应的单克隆抗体RAP 5被用于对57例晚期卵巢癌患者和28个正常卵巢进行免疫组织化学研究。各种肿瘤标本的染色模式与正常卵巢的生发上皮相似，然而，癌组织中的染色强度比正常卵巢更强。但是，我们发现RAP 5的染色强度与组织学类型、组织学分级、倍体类别及临床结果之间缺乏相关性。
