Jewell L D, Barr J R, McCaughey W T, Nguyen G K, Owen D A
Canadian Tumor Reference Centre, Ottawa.
Arch Pathol Lab Med. 1988 Feb;112(2):197-9.
We report four cases of primary clear-cell adenoma and adenocarcinoma of the large intestine. The neoplasms grossly resembled ordinary colonic adenomas and adenocarcinomas but microscopically were composed of uniform cells with optically clear cytoplasm. Mucin stains were negative, and the clear nature of the cytoplasm was due to glycogen accumulation. Areas of transition between normal colonic epithelial constituents and the clear-cell lesion were observed. Three of the four cases stained strongly positively for carcinoembryonic antigen. These lesions are apt to give rise to considerable diagnostic confusion and, in particular, resemble metastatic renal cell carcinoma. The usual strong positive carcinoembryonic antigen reaction is helpful in establishing this diagnosis.
我们报告了4例大肠原发性透明细胞腺瘤和腺癌。这些肿瘤大体上类似于普通结肠腺瘤和腺癌，但显微镜下由具有透明细胞质的均匀细胞组成。黏液染色呈阴性，细胞质的透明性质是由于糖原积累所致。观察到正常结肠上皮成分与透明细胞病变之间的过渡区域。4例中的3例癌胚抗原染色呈强阳性。这些病变容易引起相当大的诊断困惑，尤其是与转移性肾细胞癌相似。通常强烈的癌胚抗原阳性反应有助于确立这一诊断。
