在FMLP刺激的肺泡巨噬细胞中，花生四烯酸从二酰基和醚连接的磷脂中动员出来。
Mobilization of arachidonic acid from diacyl and ether-linked phospholipids in FMLP stimulated alveolar macrophages.
作者信息
Masliah J, Bachelet M, Colard O, Bereziat G, Vargaftig B B
机构信息
Laboratoire de Biochimie, C.H.U.-Saint-Antoine, Paris, France.
出版信息
Biochem Pharmacol. 1988 Feb 1;37(3):547-50. doi: 10.1016/0006-2952(88)90227-4.
Exposure of [1 14C]AA labeled guinea-pig alveolar macrophages to FMLP for 15 min induced an extensive mobilization of AA from phospholipids. PC and PI mainly contributed to the AA release, and labeled PE remained unchanged. Analysis of ether-linked phospholipids showed a significant breakdown of labeled diacyl and alkyl-acyl PC and an increase in labeled alkenyl-acyl PE.
用[1,14C]花生四烯酸（AA）标记豚鼠肺泡巨噬细胞，使其暴露于N-甲酰甲硫氨酰-亮氨酰-苯丙氨酸（FMLP）15分钟，可诱导花生四烯酸从磷脂中大量动员出来。磷脂酰胆碱（PC）和磷脂酰肌醇（PI）对花生四烯酸的释放起主要作用，而标记的磷脂酰乙醇胺（PE）则保持不变。对醚键连接的磷脂分析表明，标记的二酰基和烷基酰基PC发生了显著分解，而标记的烯基酰基PE有所增加。
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