Univ. Bordeaux, Inserm, Bordeaux Population Health Research Centre, Pharmacoepidemiology research team, UMR 1219, F-33000 Bordeaux, France; Hospital Charles Perrens. F-33000 Bordeaux. France.
Univ. Bordeaux, Inserm, Bordeaux Population Health Research Centre, Pharmacoepidemiology research team, UMR 1219, F-33000 Bordeaux, France; University Hospital, F-33000 Bordeaux, France.
Psychiatry Res. 2020 Sep;291:113276. doi: 10.1016/j.psychres.2020.113276. Epub 2020 Jul 8.
To investigate the association between the use of anxiolytic/hypnotic drugs and suicidal thoughts and/or behavior (STB) in students.
12,112 participants who completed the baseline questionnaire in the i-Share cohort between April 2013 and March 2017 were included. STB were defined at inclusion as suicidal thoughts over the previous year and/or a lifetime suicide attempt. The use of prescribed anxiolytic/hypnotic drugs over the previous 3 months was measured at baseline and follow-up time points (in 2,919 students). Psychiatric disorders were assessed through validated scales. Multivariate logistic regression models were run using disease risk score.
At inclusion, 25.2% of students had STB and 10.3% used anxiolytics/hypnotics. STB at baseline were associated with a more frequent use of anxiolytics/hypnotics in the previous 3 months, after adjustment for covariates including anxiety, depression, sleep, impulsivity, and substance use. The use of anxiolytics/hypnotics at baseline was not associated with the occurrence, persistence or remission of STB one year later. STB at baseline were associated with a new anxiolytic/hypnotic treatment one year later.
Anxiolytic/hypnotic drug use was associated with STB in students independently of many risk factors of suicide and most psychiatric disorders that require such treatment, which raises drug safety concerns.
调查在学生中使用抗焦虑/催眠药物与自杀意念和/或行为（STB）之间的关联。
共纳入了 12112 名参与者，他们在 2013 年 4 月至 2017 年 3 月期间完成了 i-Share 队列的基线问卷。STB 的定义为过去一年的自杀意念和/或终生自杀企图。在基线和随访时间点（在 2919 名学生中）测量过去 3 个月内规定使用的抗焦虑/催眠药物。通过验证量表评估精神疾病。使用疾病风险评分运行多变量逻辑回归模型。
在纳入时，25.2%的学生有 STB，10.3%使用了抗焦虑/催眠药物。在调整焦虑、抑郁、睡眠、冲动和物质使用等混杂因素后，基线时的 STB 与过去 3 个月内更频繁地使用抗焦虑/催眠药物相关。基线时使用抗焦虑/催眠药物与 STB 一年后是否发生、持续或缓解无关。基线时的 STB 与一年后新的抗焦虑/催眠治疗相关。
在学生中，抗焦虑/催眠药物的使用与 STB 独立相关，与许多自杀风险因素和需要此类治疗的大多数精神疾病无关，这引起了药物安全性的担忧。
