Bordeaux Population Health Research Center, INSERM UMR1219, Team HEALTHY, 33000 Bordeaux, France; University of Bordeaux, 33076 Bordeaux, France.
Bordeaux Population Health Research Center, INSERM UMR1219, Team HEALTHY, 33000 Bordeaux, France; University of Bordeaux, 33076 Bordeaux, France; McGill Group for Suicide Studies, Douglas Mental Health University Institure, McGill University, Montreal, Quebec, Canada.
Psychiatry Res. 2020 Sep;291:113284. doi: 10.1016/j.psychres.2020.113284. Epub 2020 Jul 6.
The association between Attention Deficit Hyperactivity Disorder (ADHD) and suicidal ideation has been the focus of recent research interest among youths and young adults. However, the role perceived stress plays in this association is unclear. We investigated whether perceived stress accounts for the association between ADHD and subsequent suicidal ideation among French students enrolled in the i-Share cohort. The associations between ADHD symptoms, perceived stress at baseline, and suicidal ideation during follow-up were investigated using logistic regression models, and Structural Equation Modeling was used to estimate the indirect effect via perceived stress. In total 4333 participants (median age: 20.3 years; [interquartile range: 18.7-21.8]) were included in the main analyses. ADHD was associated with suicidal ideation (adjusted Odds Ratio = 1.15 [95% Confidence Interval: 1.04-1.26]). Perceived stress partially accounts for the association between ADHD and suicidal ideation (proportion explained 49%). Our study suggests that ADHD and perceived stress represent mental health targets for suicide prevention programs.
注意缺陷多动障碍（ADHD）与自杀意念之间的关联一直是青少年和年轻成年人最近研究的重点。然而，感知到的压力在这种关联中所起的作用尚不清楚。我们研究了感知压力是否可以解释法国 i-Share 队列中学生中 ADHD 与随后自杀意念之间的关联。使用逻辑回归模型研究了 ADHD 症状、基线时的感知压力与随访期间自杀意念之间的关联，并使用结构方程模型来估计通过感知压力的间接效应。在主要分析中，共纳入了 4333 名参与者（中位数年龄：20.3 岁；[四分位距：18.7-21.8]）。ADHD 与自杀意念相关（调整后的优势比=1.15 [95%置信区间：1.04-1.26]）。感知压力部分解释了 ADHD 和自杀意念之间的关联（解释比例为 49%）。我们的研究表明，ADHD 和感知压力是预防自杀计划中心理健康的目标。
