Larsson K, Sollevi A
Research Department, National Board of Occupational Safety and Health, Solna, Sweden.
Chest. 1988 Feb;93(2):280-4. doi: 10.1378/chest.93.2.280.
Adenosine has been found to contract human bronchial smooth muscle in vitro and to induce bronchoconstriction in asthmatic patients when administered by inhalation. The aim of the present study was to investigate if elevation of circulating levels of adenosine influence bronchial tone or bronchial reactivity. Seven patients with bronchial asthma in whom bronchial hyperreactivity had been confirmed in a pretrial bronchial histamine challenge (PC20 FEV1 0.064 to 2.45 mg/ml) received intravenous infusions of adenosine in increasing doses (10, 30 and 50 micrograms/kg/min, 6 min on each dose step) or placebo (saline solution) on two different days in a randomized, single-blind manner. Heart rate, blood pressure and lung function (lung volumes, flow-volume loops and airway conductance) were measured on each dose step. Infusion rate was held constant (at 50 micrograms/kg/min) throughout the trial and a bronchial methacholine challenge was performed during the infusion of adenosine or placebo. Infusions of adenosine and placebo did not influence heart rate, blood pressure or bronchial tone on either day and bronchial reactivity was similar on both days. We conclude that bronchial tone and bronchial reactivity in asthmatic patients are not increased by intravenously administered adenosine at a dose level which, in other studies, has been shown to induce regional effects in the systemic arterial circulation.
已发现腺苷在体外可使人类支气管平滑肌收缩，并在哮喘患者吸入给药时诱发支气管收缩。本研究的目的是调查循环中腺苷水平升高是否会影响支气管张力或支气管反应性。七名支气管哮喘患者在预先进行的支气管组胺激发试验（PC20 FEV1为0.064至2.45毫克/毫升）中已证实存在支气管高反应性，他们在两个不同日期以随机、单盲方式接受静脉输注递增剂量的腺苷（10、30和50微克/千克/分钟，每个剂量步骤持续6分钟）或安慰剂（生理盐水）。在每个剂量步骤测量心率、血压和肺功能（肺容积、流量-容积环和气道传导率）。在整个试验过程中输注速率保持恒定（50微克/千克/分钟），并在输注腺苷或安慰剂期间进行支气管乙酰甲胆碱激发试验。腺苷和安慰剂输注在任何一天均未影响心率、血压或支气管张力，且两天的支气管反应性相似。我们得出结论，在其他研究中已显示能在体循环动脉中诱发局部效应的剂量水平下，静脉注射腺苷不会增加哮喘患者的支气管张力和支气管反应性。
