Department of Orthodontics, School and Hospital of Stomatology, Hebei Medical University & Hebei Key Laboratory of Stomatology, No. 383, East Zhongshan Road, Shijiazhuang, 050017, Hebei, People's Republic of China.
Sci Rep. 2020 Aug 6;10(1):13261. doi: 10.1038/s41598-020-70238-0.
The aim of this study was to investigate the effects of mandibular advancement device (MAD) therapy for obstructive sleep apnea-hypopnea syndrome (OSAHS) on hypoxia-inducible factor-1α (HIF-1α), erythropoietin (EPO) and vascular endothelial growth factor (VEGF) in myocardial tissue. New Zealand rabbits were used to develop OSAHS and MAD models. Cone beam computed tomography (CBCT) of the upper airway and polysomnography (PSG) recordings were performed with the animals in the supine position. All of the animals were induced to sleep in a supine position for 4-6 h each day and were observed continuously for 8 weeks. The myocardial tissue of the three groups was dissected to measure the expression of HIF-1α, EPO and VEGF. The results showed that there was higher expression of HIF-1α, EPO and VEGF in the OSAHS group than those in the MAD and control groups. MAD treatment significantly downregulated the expression of HIF-1α, EPO and VEGF in the OSAHS animals. We concluded that MAD treatment could significantly downregulate the increased expression of HIF-1α, EPO and VEGF in OSAHS rabbits, improving their myocardial function.
本研究旨在探讨下颌前移装置（MAD）治疗阻塞性睡眠呼吸暂停低通气综合征（OSAHS）对心肌组织中缺氧诱导因子-1α（HIF-1α）、促红细胞生成素（EPO）和血管内皮生长因子（VEGF）的影响。采用新西兰兔建立 OSAHS 和 MAD 模型。在仰卧位下对动物进行上气道锥形束 CT（CBCT）和多导睡眠图（PSG）记录。每天让所有动物仰卧位睡眠 4-6 小时，并连续观察 8 周。切取三组心肌组织，测量 HIF-1α、EPO 和 VEGF 的表达。结果显示，OSAHS 组 HIF-1α、EPO 和 VEGF 的表达高于 MAD 和对照组。MAD 治疗可显著下调 OSAHS 动物 HIF-1α、EPO 和 VEGF 的表达。结论：MAD 治疗可显著下调 OSAHS 兔 HIF-1α、EPO 和 VEGF 的表达增加，改善心肌功能。
