Ramos Joyce S, Dalleck Lance C, Stennett Rebecca C, Mielke Gregore I, Keating Shelley E, Murray Lydia, Hasnain Sumaira Z, Fassett Robert G, McGuckin Michael, Croci Ilaria, Coombes Jeff S
Centre for Research on Exercise, Physical Activity and Health, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Queensland, Australia.
Caring Futures Institute and SHAPE Research Centre, Exercise Science and Clinical Exercise Physiology, College of Nursing and Health Sciences, Flinders University, Adelaide, South Australia, Australia.
Diabetes Metab Syndr Obes. 2020 Jul 9;13:2443-2453. doi: 10.2147/DMSO.S251567. eCollection 2020.
IL-22 may have a role in the alleviation of the metabolic syndrome (MetS) via protection of pancreatic beta and endothelial cells from oxidative and lipid-induced damage. We aimed to investigate the effects of moderate-intensity continuous training (MICT) and different volumes of high-intensity interval training (HIIT) on changes in circulating IL-22.
This was a sub-study of the "Exercise in the prevention of Metabolic Syndrome" (EX-MET) a multi-center, randomized trial. This study used data collected at the Brisbane site. Thirty-nine individuals with MetS were randomized to one of three 16-wk interventions: 1) MICT (n=10, 30min at 60-70% HR peak, 5x/wk); 2) 4HIIT (n=13, 4x4min at 85-95% HR peak, interspersed with 3min of active recovery at 50-70% HR peak, 3x/wk); or 3) 1HIIT (n=16, 1x4min at 85-95% HR peak, 3x/wk). Serum IL-22 concentration was measured following a 12-hr fast via an enzyme linked immunosorbent assay, before and after the intervention. MetS severity, insulin resistance (IR), visceral adipose tissue (VAT), and cardiorespiratory fitness (CRF) were also measured via MetS z-score, HOMA-IR, dual-energy X-ray absorptiometry, and indirect calorimetry (maximal exercise test), respectively.
The median (IQR) IL-22% changes from pre- to post-intervention in the MICT, 4HIIT, and 1HIIT groups were -17% (-43.0% to 31.3%), +16.5% (-18.9% to 154.9%), and +15.9% (-28.7% to 46.1%), respectively. Although there were no significant between-group differences in IL-22 concentration change, there was a medium-to-large group × time interaction effect [F(2,35)=2.08, p=0.14, η=0.14].
Although there was no statistically significant between-group difference in IL-22 change, the study suggests that different exercise intensities may have opposing effects on IL-22 concentration in individuals with MetS.
白细胞介素-22（IL-22）可能通过保护胰腺β细胞和内皮细胞免受氧化和脂质诱导的损伤，在缓解代谢综合征（MetS）中发挥作用。我们旨在研究中等强度持续训练（MICT）和不同运动量的高强度间歇训练（HIIT）对循环中IL-22变化的影响。
这是一项多中心随机试验“运动预防代谢综合征”（EX-MET）的子研究。本研究使用了在布里斯班站点收集的数据。39名患有MetS的个体被随机分配到三种16周干预措施中的一种：1）MICT（n = 10，60 - 70%心率峰值下运动30分钟，每周5次）；2）4HIIT（n = 13，85 - 95%心率峰值下每次运动4分钟，共4次，每次运动之间穿插50 - 70%心率峰值下3分钟的主动恢复，每周3次）；或3）1HIIT（n = 16，85 - 95%心率峰值下运动1次，每次4分钟，每周3次）。干预前后，通过酶联免疫吸附测定法在禁食12小时后测量血清IL-22浓度。还分别通过MetS z评分、稳态模型评估胰岛素抵抗（HOMA-IR）、双能X线吸收法和间接量热法（最大运动试验）测量MetS严重程度、胰岛素抵抗（IR）、内脏脂肪组织（VAT）和心肺适能（CRF）。
MICT组、4HIIT组和1HIIT组干预前后IL-22%变化的中位数（四分位间距）分别为-17%（-43.0%至31.3%）、+16.5%（-18.9%至154.9%）和+15.9%（-28.7%至46.1%）。尽管各组之间IL-22浓度变化无显著差异，但存在中到大型的组×时间交互效应[F(2,35)=2.08，p = 0.14，η = 0.14]。
尽管各组之间IL-22变化没有统计学上的显著差异，但该研究表明不同运动强度可能对患有MetS的个体的IL-22浓度产生相反的影响。
