Victorin K, Ståhlberg M
National Institute of Environmental Medicine, Department of Toxicology, Stockholm, Sweden.
Environ Mol Mutagen. 1988;11(1):79-90. doi: 10.1002/em.2850110109.
In order to investigate the possible formation of mutagenic compounds from alkenes emitted in ambient air, laboratory experiments were performed with Salmonella typhimurium strain TA100 in a small-scale flow-through exposure system. The reaction time for mixtures of alkenes with ozone or nitrogen dioxide was 40 minutes, and the exposure time for bacteria was 6 hours. Ozone gave rise to a small mutagenic effect in combination with 1,3-butadiene or vinyl chloride, with and without ultraviolet (UV) irradiation, but not in combination with ethene or propene. Nitrogen dioxide gave rise to a mutagenic effect in combination with propene, 1,3-butadiene, or vinyl chloride, but only after UV irradiation. The mutagenic activity was highest with butadiene and seemed to be dose-related to the concentration of nitrogen dioxide. Nitrogen dioxide with ethene did not produce a mutagenic effect. A mixture of ethene, propene, and butadiene, tested with ozone or nitrogen dioxide with UV irradiation, did not potentiate each other's mutagenic effect.
为了研究环境空气中排放的烯烃可能形成诱变化合物的情况，在小型流通式暴露系统中用鼠伤寒沙门氏菌TA100菌株进行了实验室实验。烯烃与臭氧或二氧化氮混合物的反应时间为40分钟，细菌的暴露时间为6小时。臭氧与1,3 - 丁二烯或氯乙烯组合时，无论有无紫外线（UV）照射，都会产生轻微的诱变作用，但与乙烯或丙烯组合时则不会。二氧化氮与丙烯、1,3 - 丁二烯或氯乙烯组合时会产生诱变作用，但仅在紫外线照射后。丁二烯的诱变活性最高，且似乎与二氧化氮浓度呈剂量相关。二氧化氮与乙烯组合不会产生诱变作用。乙烯、丙烯和丁二烯的混合物，在紫外线照射下用臭氧或二氧化氮测试时，不会增强彼此的诱变作用。
