Șandru Florica, Popa Adelina, Petca Aida, Miulescu Raluca-Gabriela, Constantin Maria Magdalena, Petca Răzvan-Cosmin, Constantin Traian, Dumitrașcu Mihai Cristian
'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Department of Dermatology, 'Elias' Emergency University Hospital, 011461 Bucharest, Romania.
Exp Ther Med. 2020 Sep;20(3):2373-2376. doi: 10.3892/etm.2020.8815. Epub 2020 May 29.
Morphea is an inflammatory skin disease with self-limited evolution, presenting as localized sclerosis of the skin and/or underlying tissues. The incidence is not exactly known; the disease occurs more frequently in women, and there is no sex prevalence. Pathogenesis of morphea remains still controversial. Several theories exist and the infection is not yet elucidated. The aim of this report is to present the main mechanisms involved in the etiophatogenesis of morphea and also the thepapeutic options. A case of a 60-year-old woman is presented, who was referred to the clinic for an erythematous-violaceus, asymptomatic eruption, located on the trunk and legs, for appoximately 2 months. The patient's medical history revealed an infection with 1 year previously. After diagnosis of morphea was established, and with systemic therapy (corticosteroids and methotrexate), the evolution was favorable.
硬斑病是一种具有自限性病程的炎症性皮肤病，表现为皮肤和/或皮下组织的局限性硬化。其发病率尚不完全清楚；该疾病在女性中更为常见，且无性别差异。硬斑病的发病机制仍存在争议。有多种理论，感染因素尚未阐明。本报告的目的是介绍硬斑病发病机制中的主要机制以及治疗选择。报告了一例60岁女性病例，该患者因躯干和腿部出现约2个月的紫红色、无症状皮疹而转诊至诊所。患者病史显示1年前曾有感染。硬斑病诊断确立后，经全身治疗（皮质类固醇和甲氨蝶呤），病情好转。
