Xie Catherine B, Cowper Shawn, Odell Ian D
Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
Department of Dermatology, School of Medicine, Yale University, New Haven, CT, USA.
J Scleroderma Relat Disord. 2021 Feb;6(1):111-113. doi: 10.1177/2397198320956892. Epub 2020 Sep 16.
Morphea, also known as localized scleroderma, is characterized by inflammation and fibrosis of the skin. The exact pathogenesis of morphea is unknown, but generally includes genetic predisposition to autoimmunity combined with an environmental insult. Previous cases have been associated with active infection; however, infection as a direct cause of morphea was not generalizable to most patients. Within endemic areas, is the most common cause of facial nerve paralysis, another autoimmune phenomenon. We report a case of facial morphea in a young man with family history of autoimmune disease who developed morphea in the same location as two previous episodes of -induced facial nerve palsy. This case is remarkable because it suggests induced loss of local immune tolerance to host antigens, first with facial nerve palsy and followed years later by development of morphea.
硬斑病，也称为局限性硬皮病，其特征是皮肤炎症和纤维化。硬斑病的确切发病机制尚不清楚，但一般包括自身免疫的遗传易感性与环境损伤相结合。先前的病例与活动性感染有关；然而，感染作为硬斑病的直接原因并不能推广到大多数患者。在流行地区，[此处原文缺失相关内容]是面神经麻痹（另一种自身免疫现象）最常见的原因。我们报告一例年轻男性面部硬斑病病例，该患者有自身免疫病家族史，其硬斑病发生在之前两次[此处原文缺失相关内容]诱发的面神经麻痹的同一部位。该病例值得注意，因为它提示[此处原文缺失相关内容]诱导对宿主抗原的局部免疫耐受丧失，先是面神经麻痹，数年后继而出现硬斑病。
