单核细胞/高密度脂蛋白胆固醇比值升高与接受 PCI 的冠心病患者的死亡率相关。
An elevated monocyte-to-high-density lipoprotein-cholesterol ratio is associated with mortality in patients with coronary artery disease who have undergone PCI.
机构信息
Heart Center and Beijing Key Laboratory of Hypertension Disease, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, P.R. China.
出版信息
Biosci Rep. 2020 Aug 28;40(8). doi: 10.1042/BSR20201108.
BACKGROUND
The aim of the present study was to investigate the association between the monocyte-to-high-density lipoprotein-cholesterol ratio (MHR) and the outcomes of patients with coronary artery disease (CAD) who were treated with percutaneous coronary intervention (PCI).
METHODS
A total of 5679 CAD patients from CORFCHD-PCI, a retrospective cohort study (identifier: ChiCTR-ORC-16010153), who underwent PCI were included in the study and divided into three tertiles according to their MHR values. The primary outcome was long-term mortality after PCI. The main secondary endpoints were stroke, readmission, and major adverse cardiovascular events (MACEs), defined as the combination of cardiac death, recurrent myocardial infarction, and target vessel reconstruction. The average follow-up time was 35.9 ± 22.6 months.
RESULTS
Patients were divided into three groups according to MHR tertiles: the first tertile (MHR < 0.4; n=1290), second tertile (MHR ≥ 0.4-0.61; n=1878) and third tertile (MHR > 0.61; n=1870). The all-cause mortality (ACM) incidence was significantly lower in the first and second tertiles than in the third tertile (adjusted HR = 0.658, [95% CI: 0.408-0.903], P=0.009 and HR = 0.712, [95% CI: 0.538-0.941], P=0.017, respectively). Cardiac mortality (CM) occurred in 235 patients: 60 (3.1%) in the first tertile group, 74 (3.9%) in the second tertile group and 101 (5.4%) in the third tertile group. There was a significant difference in the CM incidence between the first tertile group and the third tertile group (HR = 0.581, [95% CI: 0.406-0.832], P=0.003), and there was also a difference in the CM incidence between the second tertile group and the third tertile group (HR = 0.690, [95% CI: 0.506-0.940], P=0.019).
CONCLUSION
The present study indicated that an increased MHR was independently associated with long-term mortality in CAD patients who have undergone PCI.
背景
本研究旨在探讨单核细胞/高密度脂蛋白胆固醇比值（MHR）与接受经皮冠状动脉介入治疗（PCI）的冠心病（CAD）患者结局之间的关系。
方法
本研究纳入了来自 CORFCHD-PCI 的 5679 名 CAD 患者，这是一项回顾性队列研究（标识符：ChiCTR-ORC-16010153），根据 MHR 值将其分为三组。主要终点是 PCI 后的长期死亡率。主要次要终点是中风、再入院和主要不良心血管事件（MACE），定义为心脏死亡、复发性心肌梗死和靶血管重建的组合。平均随访时间为 35.9±22.6 个月。
结果
根据 MHR 三分位值，患者分为三组：第一三分位组（MHR<0.4；n=1290）、第二三分位组（MHR≥0.4-0.61；n=1878）和第三三分位组（MHR>0.61；n=1870）。全因死亡率（ACM）发生率在第一和第二三分位组明显低于第三三分位组（调整 HR=0.658，[95%CI：0.408-0.903]，P=0.009 和 HR=0.712，[95%CI：0.538-0.941]，P=0.017）。共发生 235 例心脏性死亡（CM）：第一三分位组 60 例（3.1%），第二三分位组 74 例（3.9%），第三三分位组 101 例（5.4%）。第一三分位组与第三三分位组 CM 发生率差异有统计学意义（HR=0.581，[95%CI：0.406-0.832]，P=0.003），第二三分位组与第三三分位组 CM 发生率差异也有统计学意义（HR=0.690，[95%CI：0.506-0.940]，P=0.019）。
结论
本研究表明，MHR 升高与接受 PCI 的 CAD 患者的长期死亡率独立相关。
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