R&D Department, Lo.Li. Pharma S.r.l., Rome, Italy.
Eur Rev Med Pharmacol Sci. 2020 Aug;24(15):8187-8193. doi: 10.26355/eurrev_202008_22507.
The ongoing worldwide pandemic of Coronavirus disease 2019 (COVID-19), raised the urgency to address knowledge gaps and to establish evidence for improving management and control of this viral infection. Throughout a keen analysis of the World Health Organization (WHO) most updated data, a gender-specific difference in the occurrence of infection was determined, which seems to correlate with patient's vitamin D status. Therefore, our purpose is to provide insights into the nutritional importance of vitamin D for its immunomodulatory effect, in order to help counteracting the COVID-19 pandemic. Novel interesting findings suggest that vitamin D, by inducing progesterone-induced blocking factor (PIBF), might regulate the immune response and also modulate cytokine IL-6, which appears to be increased in COVID-19 infections. Therefore, in addition to the standard recommendations to prevent the infection, supplementation of vitamin D might be considered an approach to help counteracting this global epidemic.
持续的 2019 年冠状病毒病（COVID-19）全球大流行，凸显出解决知识空白和为改善这种病毒感染的管理和控制提供证据的紧迫性。通过对世界卫生组织（WHO）最新数据的深入分析，确定了感染发生率的性别差异，这似乎与患者的维生素 D 状况有关。因此，我们的目的是深入了解维生素 D 的营养重要性，因为它具有免疫调节作用，以帮助应对 COVID-19 大流行。新的有趣发现表明，维生素 D 通过诱导孕激素诱导阻断因子（PIBF），可能调节免疫反应，并调节细胞因子 IL-6，而 COVID-19 感染中似乎增加了细胞因子 IL-6。因此，除了预防感染的标准建议外，补充维生素 D 可能被视为一种有助于应对这一全球流行的方法。
