Fletcher Nicholas L, Kempe Kristian, Thurecht Kristofer J
Centre for Advanced Imaging (CAI) and Australian Institute for Bioengineering and Nanotechnology (AIBN), ARC Centre of Excellence in Convergent Bio-Nano Science and Technology and ARC Training Centre for Innovation in Biomedical Imaging Technology, The University of Queensland, St. Lucia, QLD, 4072, Australia.
Materials Science and Engineering, Monash University, Clayton, VIC, 3800, Australia.
Macromol Rapid Commun. 2020 Sep;41(18):e2000319. doi: 10.1002/marc.202000319. Epub 2020 Aug 7.
Precision polymers as advanced nanomedicines represent an appealing approach for the treatment of otherwise untreatable malignancies. By taking advantage of unique nanomaterial properties and implementing judicious design strategies, polymeric nanomedicines are able to be produced that overcome many barriers to effective treatment. Current key research focus areas anticipated to produce the greatest impact in polymer applications in nanomedicine for oncology include new strategies to achieve "active" targeting, polymeric pro-drug activation, and combinatorial polymer drug delivery approaches in combination with enhanced understanding of complex bio-nano interactions. These approaches, both in isolation or combination, form the next generation of precision nanomedicines with significant anticipated future health outcomes. Of necessity, these approaches will combine an intimate understanding of biological interactions with advanced materials design. This perspectives piece aims to highlight emerging opportunities that promise to be game changers in the nanomedicine oncology field. Discussed herein are current and next generation polymeric nanomedicines with a focus towards structures that are, or could, undergo clinical translation as well as highlight key advances in the field.
精密聚合物作为先进的纳米药物，是治疗难以治疗的恶性肿瘤的一种有吸引力的方法。通过利用独特的纳米材料特性并实施明智的设计策略，可以生产出克服有效治疗诸多障碍的聚合物纳米药物。目前预计在肿瘤学纳米医学的聚合物应用中产生最大影响的关键研究重点领域包括实现“主动”靶向的新策略、聚合物前药激活以及与对复杂生物-纳米相互作用的深入理解相结合的组合聚合物药物递送方法。这些方法单独或组合使用，构成了具有重大预期未来健康成果的下一代精密纳米药物。这些方法必然会将对生物相互作用的深入理解与先进的材料设计相结合。这篇观点文章旨在突出有望成为纳米医学肿瘤学领域游戏规则改变者的新兴机会。本文讨论了当前和下一代聚合物纳米药物，重点关注那些已经或可能进行临床转化的结构，并突出该领域的关键进展。
