Department of Biology, School of Medicine, University of Zagreb, Zagreb, Croatia.
Centre of Excellence in Reproductive and Regenerative Medicine, University of Zagreb School of Medicine, Zagreb, Croatia; Department of Obstetrics and Gynecology, School of Medicine, University of Zagreb, Zagreb, Croatia; Clinic of Obstetrics and Gynecology, Clinical Hospital "Sveti Duh", Zagreb, Croatia.
Bosn J Basic Med Sci. 2021 Feb 1;21(1):5-18. doi: 10.17305/bjbms.2020.5036.
Glycogen synthase kinase 3 (GSK3) is a monomeric serine-threonine kinase discovered in 1980 in a rat skeletal muscle. It has been involved in various cellular processes including embryogenesis, immune response, inflammation, apoptosis, autophagy, wound healing, neurodegeneration, and carcinogenesis. GSK3 exists in two different isoforms, GSK3α and GSK3β, both containing seven antiparallel beta-plates, a short linking part and an alpha helix, but coded by different genes and variously expressed in human tissues. In the current review, we comprehensively appraise the current literature on the role of GSK3 in various cancers with emphasis on ovarian carcinoma. Our findings indicate that the role of GSK3 in ovarian cancer development cannot be decisively determined as the currently available data support both prooncogenic and tumor-suppressive effects. Likewise, the clinical impact of GSK3 expression on ovarian cancer patients and its potential therapeutic implications are also limited. Further studies are needed to fully elucidate the pathophysiological and clinical implications of GSK3 activity in ovarian cancer.
糖原合酶激酶 3（GSK3）是一种单体丝氨酸/苏氨酸激酶，于 1980 年在大鼠骨骼肌中发现。它参与了多种细胞过程，包括胚胎发生、免疫反应、炎症、细胞凋亡、自噬、伤口愈合、神经退行性变和癌症发生。GSK3 存在两种不同的同工酶形式，GSK3α 和 GSK3β，都含有七个反平行的β 片层、一个短连接部分和一个α 螺旋，但由不同的基因编码，在人类组织中表达不同。在本综述中，我们全面评估了 GSK3 在各种癌症中的作用的现有文献，重点是卵巢癌。我们的研究结果表明，GSK3 在卵巢癌发展中的作用不能被确定，因为目前可用的数据支持致癌和肿瘤抑制作用。同样，GSK3 表达对卵巢癌患者的临床影响及其潜在的治疗意义也有限。需要进一步的研究来充分阐明 GSK3 活性在卵巢癌中的病理生理和临床意义。
