Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Handb Clin Neurol. 2020;172:33-50. doi: 10.1016/B978-0-444-64240-0.00002-7.
Maternal stroke occurs in around 34 out of every 100,000 deliveries and is responsible for around 5%-12% of all maternal deaths. It is most commonly hemorrhagic, and women are at highest risk for developing pregnancy-related hemorrhage during the early postpartum period through 6 weeks following the delivery. The most common causes of hemorrhagic stroke in pregnant patients are arteriovenous malformations and cerebral aneurysms. Management is similar to that for acute hemorrhagic stroke in the nonpregnant population with standard use of computed tomography and judicious utilization of intracranial vessel imaging and contrast. The optimal delivery method is evaluated on a case-by-case basis, and cesarean delivery is not always required. As most current studies are limited by retrospective design, relatively small sample sizes, and heterogeneous study term definitions, strong and comprehensive evidence-based guidelines on the management of acute hemorrhagic stroke in pregnant patients are still lacking. In the future, multicenter registries and prospective studies with uniform definitions will help improve management strategies in this complex patient population.
产妇脑卒中的发病率约为每 10 万分娩中 34 例,约占所有孕产妇死亡的 5%-12%。其最常见的类型为出血性脑卒中,且女性在产后早期(分娩后 6 周内)发生与妊娠相关的出血风险最高。孕妇发生出血性脑卒中的最常见病因是动静脉畸形和颅内动脉瘤。其治疗与非妊娠人群的急性出血性脑卒中相似,常规使用计算机断层扫描,并合理使用颅内血管成像和造影。最佳分娩方式需根据具体情况进行评估,并非总是需要剖宫产。由于目前大多数研究受到回顾性设计、相对较小的样本量和异质性研究术语定义的限制,对于妊娠患者急性出血性脑卒中的管理仍缺乏强有力的、基于循证的综合指南。未来,多中心登记研究和具有统一定义的前瞻性研究将有助于改善这一复杂患者群体的管理策略。