免疫组织化学染色作为源于导管内乳头状黏液性肿瘤的腹膜假黏液瘤的辅助诊断工具：两例报告及文献复习。

Immunohistochemical staining as supportive diagnostic tool for pseudomyxoma peritonei arising from intraductal papillary mucinous neoplasm: A report of two cases and literature review.

机构信息

Department of Surgery, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan; Course of Advanced and Specialized Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongou, Bunkyo-ku, Tokyo, 113-8421, Japan.

Department of Surgery, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.

出版信息

Pancreatology. 2020 Sep;20(6):1226-1233. doi: 10.1016/j.pan.2020.06.008. Epub 2020 Jul 7.

DOI:10.1016/j.pan.2020.06.008

PMID:32768178

Abstract

BACKGROUND/OBJECTIVES: Pseudomyxoma peritonei (PMP) arising from an intraductal papillary mucinous neoplasm of the pancreas (IPMN) is a rare condition. The diagnosis of IPMN as the origin of PMP is mainly inferred from the clinical course and the exclusion of PMP from other organs. The pathological diagnosis has not yet been established. To evaluate the usefulness of immunohistochemical staining for the diagnosis of the primary lesion of PMP as IPMN.

METHODS

There are 2 cases of PMP arising from IPMN between March 2010 and December 2019 at National Center for Global Health and Medicine. A PubMed search that reported PMP arising from IPMN identified 16 additional cases. Diagnostic methods and clinicopathological features of 18 cases were compared.

RESULTS

Four cases including our two cases used immunohistochemical staining for the diagnosis of PMP arising from IPMN. The correspondence of the immunohistochemical staining between PMP and IPMN was shown in the three cases including previously reported two cases and one of our two cases to identify the primary lesion of PMP as IPMN. In addition, we revealed that the comparison of the immunostaining pattern of PMP with the representative immunostaining pattern of the candidate primary lesions is helpful for the diagnosis of the primary lesion of PMP.

CONCLUSIONS

Immunohistochemical staining is helpful to identify the primary lesion of PMP as IPMN.

摘要

背景/目的：源于胰腺导管内乳头状黏液性肿瘤（IPMN）的假性黏液瘤（PMP）是一种罕见的情况。PMP 源于 IPMN 的诊断主要是根据临床过程推断的，并排除了 PMP 来自其他器官的可能性。病理诊断尚未确定。评估免疫组织化学染色在诊断 PMP 源于 IPMN 的原发性病变中的作用。

方法

2010 年 3 月至 2019 年 12 月，国立全球卫生与医学研究所（National Center for Global Health and Medicine）有 2 例源于 IPMN 的 PMP。对报道源于 IPMN 的 PMP 的 PubMed 检索确定了另外 16 例。比较了 18 例的诊断方法和临床病理特征。

结果

包括我们的 2 例在内，有 4 例病例使用免疫组织化学染色来诊断源于 IPMN 的 PMP。在包括之前报道的 2 例和我们的 2 例中的 3 例中，显示了 PMP 与 IPMN 之间免疫组织化学染色的一致性，从而将 PMP 的原发性病变鉴定为 IPMN。此外，我们揭示了比较 PMP 的免疫染色模式与候选原发性病变的代表性免疫染色模式有助于诊断 PMP 的原发性病变。