Huang Shan, Lu Rui, Yang Jing-Ya, Zhou Gang
The State Key Laboratory Breeding Base of Basic Science of Stomatology (HubeiMOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, China.
The State Key Laboratory Breeding Base of Basic Science of Stomatology (HubeiMOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, China; Department of Oral Medicine, School and Hospital of Stomatology, Wuhan University, China.
J Infect Chemother. 2020 Dec;26(12):1309-1312. doi: 10.1016/j.jiac.2020.07.010. Epub 2020 Aug 5.
Syphilis, a sexually transmitted disease, can be categorized as acquired syphilis and congenital syphilis, manifesting diverse lesions involving multiple sites. Oral manifestations at the primary stage of acquired syphilis are usually characterized by its short period and non-specific varied presentations. And oral ulcers as initial and the only presentation of syphilis oral lesions are infrequent and occur in less than 2% of patients. Because of its transient nature and variable manifestations which could mimic other oral ulcerative lesions, oral syphilis presenting as sole ulceration at early stage can be easily neglected and rather difficult to diagnose. Herein, we report a 35-year-old female patient manifested a sole atypical ulceration on her upper lip for approximately 1 month. We highlighted the importance of early and accurate diagnosis, focused on the characteristics of oral chancre, and gave an insight to the differential diagnoses, which would be enlightening and useful in clinical practice.
梅毒是一种性传播疾病，可分为获得性梅毒和先天性梅毒，表现为累及多个部位的多样损害。获得性梅毒一期的口腔表现通常具有病程短和表现多样且不特异的特点。而口腔溃疡作为梅毒口腔损害的初始且唯一表现较为少见，发生率不到2%的患者。由于其具有一过性本质和可变的表现，可模仿其他口腔溃疡性损害，早期仅表现为单一溃疡的口腔梅毒很容易被忽视且诊断相当困难。在此，我们报告一名35岁女性患者，其上唇出现单一非典型溃疡约1个月。我们强调了早期准确诊断的重要性，关注口腔硬下疳的特征，并对鉴别诊断进行了深入探讨，这在临床实践中将具有启发性和实用性。
