Shinonaga M, Chang C C, Suzuki N, Sato M, Kuwabara T
Department of Neurological Surgery, Yokohama City University School of Medicine, Japan.
J Neurosurg. 1988 Feb;68(2):259-65. doi: 10.3171/jns.1988.68.2.0259.
Peritumoral edema is one of the most serious complications of intracranial neoplasms; however, the exact pathogenesis of this condition is still unknown. To explore the effect of macrophages in brain tumors on the pathogenesis of peritumoral edema, 42 specimens of primary or metastatic brain tumors were studied. Frozen sections were examined by an immunoperoxidase staining technique with anti-Leu-M3 monoclonal antibody. Eight of 14 gliomas demonstrated Leu-M3-positive cell (macrophage) infiltration. The two glioblastomas showed a moderate or marked degree of macrophage infiltration. Twelve of 16 meningiomas demonstrated varying degrees of macrophage infiltration. All six metastatic brain tumors exhibited prominent macrophages in intra- and peritumoral tissues. Four acoustic neurinomas and two hemangioblastomas showed a slight to moderate degree of macrophage infiltration. Excellent correlation was found between the degree of macrophage infiltration seen on immunoperoxidase staining and the peritumoral edema detected on computerized tomography brain scans of patients with supratentorial tumors, especially meningiomas. Macrophages are known to secrete various substances (including arachidonate metabolites) that may interfere with vascular permeability. These data suggest that macrophages infiltrating brain tumors may play an important role in the pathogenesis of peritumoral edema.
瘤周水肿是颅内肿瘤最严重的并发症之一；然而，这种情况的确切发病机制仍不清楚。为了探究脑肿瘤中的巨噬细胞在瘤周水肿发病机制中的作用，对42例原发性或转移性脑肿瘤标本进行了研究。采用抗Leu-M3单克隆抗体的免疫过氧化物酶染色技术检查冰冻切片。14例胶质瘤中有8例显示Leu-M3阳性细胞（巨噬细胞）浸润。2例胶质母细胞瘤显示出中度或显著程度的巨噬细胞浸润。16例脑膜瘤中有12例显示出不同程度的巨噬细胞浸润。所有6例转移性脑肿瘤在瘤内和瘤周组织中均表现出明显的巨噬细胞。4例听神经瘤和2例血管母细胞瘤显示出轻度至中度的巨噬细胞浸润。在幕上肿瘤患者，尤其是脑膜瘤患者的免疫过氧化物酶染色所见的巨噬细胞浸润程度与计算机断层扫描脑扫描检测到的瘤周水肿之间发现了良好的相关性。已知巨噬细胞会分泌各种可能干扰血管通透性的物质（包括花生四烯酸代谢物）。这些数据表明，浸润脑肿瘤的巨噬细胞可能在瘤周水肿的发病机制中起重要作用。
