Graduate Program in Nutrition, Universidade Federal de Pernambuco, 50670-901 Recife, PE, Brazil.
Physical Education and Sport Sciences Unit, Universidade Federal de Pernambuco, 55608-680 Vitória de Santo Antão, PE, Brazil; Phenotypic Plasticity and Nutrition Studies Unit, Universidade Federal de Pernambuco, 50670-901 Recife, PE, Brazil.
Life Sci. 2020 Oct 15;259:118224. doi: 10.1016/j.lfs.2020.118224. Epub 2020 Aug 5.
The aim of this study was to evaluate the effects of maternal exposure to a high-fat diet associated with neonatal administration of kaempferol on somatic growth, biochemical profile and feeding behavior in offspring.
Wistar rats were distributed according to diet during pregnancy and lactation into Control (C; 3.4 kcal/g; 12% kcal/lipids) or High-fat (HFD; 4.6 kcal/g; 51% kcal/lipids) groups. In the offspring, vehicle (V) or kaempferol (K, 1 mg/kg) were administered from the 8th until the 21st postnatal day (PND). Maternal body weight (BW), caloric intake and adiposity were measured. In the offspring, somatic growth parameters were evaluated on the 7th, 14th, 21st, 25th and 30th PND, except for BW, which was measured from the 8th to the 21st and from the 25th to the 30th PND. Feeding behavior was assessed by food intake and behavioral satiety sequence (BSS) on the 30th PND. The biochemical profile and relative weight of adipose tissue of offspring were also measured.
Dams exposed to HFD showed no difference in body weight and caloric intake but exhibited increased adiposity. Neonatal administration of kaempferol increased body weight after weaning and somatic growth in the offspring of HFD dams. Neonatal kaempferol also reduced adiposity and serum creatinine levels in offspring. Neither maternal diet nor kaempferol altered offspring feeding behavior.
Neonatal administration of kaempferol promotes increased somatic growth post-weaning, reduces adiposity, and does not alter feeding behavior in offspring from high-fat dams.
本研究旨在评估母体暴露于高脂肪饮食并联合新生仔鼠给予山奈酚对后代体生长、生化特征和摄食行为的影响。
Wistar 大鼠根据孕期和哺乳期饮食分为对照组（C；3.4 千卡/克；12%热量来自脂肪）或高脂肪饮食组（HFD；4.6 千卡/克；51%热量来自脂肪）。在子代中，从第 8 天至第 21 天新生期（PND）给予载体（V）或山奈酚（K，1 毫克/千克）。测量母体体重（BW）、热量摄入和肥胖程度。在子代中，除 BW 外，于第 7、14、21、25 和 30 PND 评估体生长参数，BW 于第 8 天至第 21 天及第 25 天至第 30 天测量。于第 30 PND 时通过食物摄入量和行为饱食序列（BSS）评估摄食行为。还测量了子代的生化特征和脂肪组织相对重量。
暴露于 HFD 的母鼠体重和热量摄入无差异，但肥胖程度增加。新生仔鼠给予山奈酚可增加断乳后体重和 HFD 母鼠子代的体生长。新生仔鼠给予山奈酚还降低了脂肪组织和血清肌酐水平。母体饮食或山奈酚均未改变子代摄食行为。
新生仔鼠给予山奈酚可促进断乳后体生长，减少肥胖，且不改变高脂肪饮食母鼠的子代摄食行为。
