Department of Immunology, University of Manitoba, Winnipeg, MB, Canada; Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada; Department of Internal Medicine, Section of Gastroenterology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada; IBD Clinical and Research Centre, University of Manitoba, Winnipeg, MB, Canada.
Department of Pediatric and Child Health, University of Manitoba, Winnipeg, MB, Canada.
Sleep Med. 2020 Sep;73:38-46. doi: 10.1016/j.sleep.2020.04.020. Epub 2020 Apr 30.
Sleep disorders are progressively common and sometimes are associated with aberrant regulation of the adaptive and innate immune responses. Sleep interruption can increase the inflammatory burden by enhancing the pro-inflammatory cytokines particularly in patients with chronic diseases such as inflammatory bowel disease (IBD). IBD is a chronic inflammatory disease characterized by immune dysregulation, dysbiosis of gut microbiome, and poor-quality life. Therefore, this review highlights the crosstalk between sleep and immune responses during the progression of IBD.
睡眠障碍越来越常见，有时与适应性和固有免疫反应的异常调节有关。睡眠中断会通过增强促炎细胞因子来增加炎症负担，特别是在患有慢性疾病（如炎症性肠病）的患者中。炎症性肠病是一种慢性炎症性疾病，其特征为免疫失调、肠道微生物组的失调和生活质量差。因此，本综述强调了在炎症性肠病进展过程中睡眠与免疫反应之间的相互作用。
