细颗粒物与致命性脑出血发病率之间的关联：中国上海的时间分层病例交叉研究。
Association Between Fine Particulate Matter and Fatal Hemorrhagic Stroke Incidence: A Time Stratified Case-Crossover Study in Shanghai, China.
机构信息
Songjiang District Center for Disease Control and Prevention, Shanghai, China (Dr B Cai, Dr Lu); Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China (Dr Xia, Dr R Cai, Dr Wang); Department of Oral and Craniomaxillofacial Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai JiaoTong University School of Medicine, Shanghai, China (Dr Qian).
出版信息
J Occup Environ Med. 2020 Nov;62(11):916-921. doi: 10.1097/JOM.0000000000001973.
OBJECTIVES
Evidence of the association between fine particulate (PM2.5, particles ≤2.5 μm in aerodynamic diameter) air pollution and fatal hemorrhagic stroke incidence is limited. This study aims to document the relationship between PM2.5 exposure and fatal hemorrhagic stroke incidence.
METHODS
The time-stratified case-crossover approach was applied for the analysis.
RESULTS
The mean concentration of PM2.5 is 75.33 μg/m. Fatal hemorrhagic stroke incidence was significantly associated with PM2.5 exposure. Exposure to PM2.5 led to a 5% (2%-9%) and 5% (1%-10%) increase in fatal hemorrhagic stroke incidence in lag2 and lag03 respectively. An increased risk was observed especially in men and subjects with hypertension.
CONCLUSIONS
This study provides evidence for the association between PM2.5 exposure and fatal hemorrhagic stroke incidence. Men and subjects with hypertension have increased risks, overweight may further increase their susceptibility to PM2.5 exposure related hemorrhagic stroke.
目的
细颗粒物（PM2.5，空气动力学直径≤2.5μm 的颗粒）空气污染与致命性出血性中风发病率之间关联的证据有限。本研究旨在记录 PM2.5 暴露与致命性出血性中风发病率之间的关系。
方法
采用时间分层病例交叉法进行分析。
结果
PM2.5 的平均浓度为 75.33μg/m。致命性出血性中风发病率与 PM2.5 暴露显著相关。暴露于 PM2.5 后，lag2 和 lag03 时致命性出血性中风的发病率分别增加了 5%（2%-9%）和 5%（1%-10%）。在男性和高血压患者中观察到风险增加尤其明显。
结论
本研究为 PM2.5 暴露与致命性出血性中风发病率之间的关联提供了证据。男性和高血压患者的风险增加，超重可能进一步增加他们对 PM2.5 暴露相关出血性中风的易感性。
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