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针刺耳穴肝（EX-HN6）放血作为麦粒肿滴眼液辅助治疗的Meta分析。

Bloodletting at EX-HN6 as an adjunctive therapy to eye drops for stye: A meta-analysis.

作者信息

Qiao Hong-Wei, Liu Na-Wen, Wang Jin, Huang Shan, Yu Lei, Chen Zhong

机构信息

Department of Traditional Chinese Medicine.

Department of Nursing Care, Tianjin First Central Hospital, Tianjin, China.

出版信息

Medicine (Baltimore). 2020 Aug 7;99(32):e21555. doi: 10.1097/MD.0000000000021555.

DOI:10.1097/MD.0000000000021555
PMID:32769896
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7593029/
Abstract

BACKGROUND

This study evaluated the effectiveness and safety of bloodletting (BL) at ear-apex (EX-HN6) as an adjunctive therapy to eye drops for stye.

METHODS

This study systematically searched electronic databases from inception to March 1, 2020 in PUBMED, EMBASE, Cochrane Library, China National Knowledge Infrastructure, Chinese Scientific Journals Full-text Database, and WanFang Database. All potential randomized controlled trials (RCTs) investigating the effectiveness and safety of BL at EX-HN6 as an adjunctive therapy to eye drops for stye were included in this study. Study quality of all included studies was assessed by Cochrane Risk of Bias Assessment Tool. RevMan 5.3 software was used for statistical analysis and meta-analysis performance.

RESULTS

A total of 11 RCTs, involving 1718 subjects, were included in this study. Results showed that BL at EX-HN6 as an adjunctive therapy to eye drops was superior to the eye drops alone in enhancing total effectiveness rate (risk ratio [RR] 1.21, 95% confidence intervals [CIs] [1.11, 1.32], I = 79%), and total cure rate (RR 1.28, 95% CIs [1.14, 1.43], I = 69%). After removing two studies, results of subgroup analysis still showed significant improvements in total effectiveness rate (RR 1.13, 95% CIs [1.08, 1.18], I = 0%), and total cure rate (RR 1.16, 95% CIs [1.08, 1.24], I = 0%). No data of adverse reactions was reported in primary trials, thus, this study did not analyze adverse reactions of BL at EX-HN6 as an adjunctive therapy to eye drops for stye.

CONCLUSION

BL at EX-HN6 as an adjunctive therapy to eye drops may benefit stye. However, high-quality RCTs addressing on this issue is still needed to warrant the findings of this study.

摘要

背景

本研究评估了耳尖（EX-HN6）放血作为麦粒肿眼药水辅助治疗的有效性和安全性。

方法

本研究系统检索了从数据库建立至2020年3月1日的电子数据库，包括PUBMED、EMBASE、Cochrane图书馆、中国知网、中国科学期刊全文数据库和万方数据库。所有调查耳尖放血作为麦粒肿眼药水辅助治疗的有效性和安全性的潜在随机对照试验（RCT）均纳入本研究。采用Cochrane偏倚风险评估工具评估所有纳入研究的质量。使用RevMan 5.3软件进行统计分析和荟萃分析。

结果

本研究共纳入11项RCT，涉及1718名受试者。结果显示，耳尖放血作为眼药水的辅助治疗在提高总有效率（风险比[RR]1.21，95%置信区间[CI][1.11, 1.32]，I = 79%）和总治愈率（RR 1.28，95% CI[1.14, 1.43]，I = 69%）方面优于单纯使用眼药水。剔除两项研究后，亚组分析结果仍显示总有效率（RR 1.13，95% CI[1.08, 1.18]，I = 0%）和总治愈率（RR 1.16，95% CI[1.08, 1.24]，I = 0%）有显著提高。在主要试验中未报告不良反应数据，因此，本研究未分析耳尖放血作为麦粒肿眼药水辅助治疗的不良反应。

结论

耳尖放血作为眼药水的辅助治疗可能对麦粒肿有益。然而，仍需要高质量的RCT来证实本研究的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/613e/7593029/2614c8beaf23/medi-99-e21555-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/613e/7593029/31d3c1869a90/medi-99-e21555-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/613e/7593029/469b08025d39/medi-99-e21555-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/613e/7593029/b7524d7e5f3a/medi-99-e21555-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/613e/7593029/a9df10649f22/medi-99-e21555-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/613e/7593029/dfde4332b07c/medi-99-e21555-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/613e/7593029/2614c8beaf23/medi-99-e21555-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/613e/7593029/31d3c1869a90/medi-99-e21555-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/613e/7593029/469b08025d39/medi-99-e21555-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/613e/7593029/b7524d7e5f3a/medi-99-e21555-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/613e/7593029/a9df10649f22/medi-99-e21555-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/613e/7593029/dfde4332b07c/medi-99-e21555-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/613e/7593029/2614c8beaf23/medi-99-e21555-g008.jpg

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