Chen Chang, Xu Yali, Huang Xin, Mao Feng, Shen Songjie, Xu Ying, Sun Qiang
Department of Breast Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Medicine (Baltimore). 2020 Aug 7;99(32):e21560. doi: 10.1097/MD.0000000000021560.
Breast cancer and ovarian cancer are closely related. The major common risk factors of these 2 types of cancer are likely genetic factors. However, few studies have shown any common characteristics in patients who have both types of these 2 cancers. The purpose of this retrospective study is to explore the clinical characteristics and survival outcomes of patients with both primary breast cancer and primary ovarian cancer.A cohort of patients who had a history of both primary breast cancer and primary ovarian cancer were enrolled, and they received treatment in the Peking Union Medical College Hospital between January 1, 2010, and December 31, 2018. Both descriptive statistics analysis and survival analysis were performed for analysis.A total of 114 patients with both primary breast cancer and primary ovarian cancer were included in the study. The median (range) follow-up was 129.5 (20-492) months. The average interval time between the diagnosis of 2 types of cancer was 79.4 months in patients having ovarian cancer firstly and was 115.9 months in patients having breast cancer firstly. The 5- and 10-year overall survival (OS) rates were 91.5% and 81.7% for patients with ovarian cancer following breast cancer, respectively, and 90.6% and 87.5% for patients with breast cancer following ovarian cancer, respectively. Multivariate analysis revealed that independent predictors of OS were the age of diagnosis of the first tumor and the time interval between two types of tumor in patients with ovarian cancer following breast cancer.Most breast cancer or ovarian cancer occurred within 5 years after being diagnosed with the first tumor, and the interval time was significantly shorter in patients with previous ovarian cancer. The prognosis is likely positively correlated to the interval time between the occurrences of two types of cancer.
乳腺癌和卵巢癌密切相关。这两种癌症的主要共同风险因素可能是遗传因素。然而，很少有研究表明同时患有这两种癌症的患者有任何共同特征。这项回顾性研究的目的是探讨原发性乳腺癌和原发性卵巢癌患者的临床特征和生存结果。
纳入了一组有原发性乳腺癌和原发性卵巢癌病史的患者，他们于2010年1月1日至2018年12月31日在北京协和医院接受治疗。进行描述性统计分析和生存分析。
该研究共纳入114例原发性乳腺癌和原发性卵巢癌患者。中位（范围）随访时间为129.5（20 - 492）个月。首先诊断为卵巢癌的患者，两种癌症诊断之间的平均间隔时间为79.4个月；首先诊断为乳腺癌的患者，平均间隔时间为115.9个月。乳腺癌后发生卵巢癌的患者，5年和10年总生存率（OS）分别为91.5%和81.7%；卵巢癌后发生乳腺癌的患者，5年和10年总生存率分别为90.6%和87.5%。多因素分析显示，乳腺癌后发生卵巢癌的患者中，总生存的独立预测因素是首次肿瘤诊断时的年龄和两种肿瘤之间的时间间隔。
大多数乳腺癌或卵巢癌发生在首次肿瘤诊断后的5年内，既往有卵巢癌的患者间隔时间明显更短。预后可能与两种癌症发生之间的间隔时间呈正相关。
