出血后脑积水的分流结果：系统评价与荟萃分析方案
Shunting outcomes in post-hemorrhagic hydrocephalus: A protocol for systematic review and meta-analysis.
作者信息
Sun Tong, Guan Junwen, You Chao, Yang Jingguo, Li Xuepei, Yuan Yikai, Zhou Yicheng
机构信息
Department of Neurosurgery.
West China Brain Research Center, West China Hospital.
出版信息
Medicine (Baltimore). 2020 Aug 7;99(32):e21640. doi: 10.1097/MD.0000000000021640.
BACKGROUND
The best treatment option for patients with post-hemorrhagic hydrocephalus (PHH) remains controversial. The objective of the current meta-analysis is to systematically evaluate the long-term outcomes of patients with PHH treated by ventriculoperitoneal shunt (VPS) and lumboperitoneal shunt (LPS).
METHODS
We search literatures through PubMed, Web of Science, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), the Chinese Science and Technology Periodical Database (VIP) and Wan fang databases, and Chinese Biomedical Literature Database (CBM) from its beginning to June 15, 2020. Randomized controlled trials (RCTs) and non-RCTs in English or Chinese studies will be considered. The primary outcome is the rate of shunt failure after shunt implantationThe secondary outcome is the rate of complications that are associated with shunt surgery.
RESULTS AND CONCLUSION
The study will compare the 2 types of shunt surgery in the treatment of PHH, providing evidence for the treatment option for the patients with PHH.
STUDY REGISTRATION NUMBER
The study is priorly registered through International Platform of Registered Systematic Review and Meta-analysis Protocols on June 17, 2020 (INPLASY202060063).
背景
出血后脑积水（PHH）患者的最佳治疗方案仍存在争议。本荟萃分析的目的是系统评价经脑室腹腔分流术（VPS）和腰大池腹腔分流术（LPS）治疗的PHH患者的长期预后。
方法
我们通过PubMed、科学网、Embase、考克兰图书馆、中国知网、维普数据库和万方数据库以及中国生物医学文献数据库（CBM）检索从建库至2020年6月15日的文献。将纳入英文或中文研究中的随机对照试验（RCT）和非RCT。主要结局是分流植入术后的分流失败率。次要结局是与分流手术相关的并发症发生率。
结果与结论
本研究将比较两种分流手术治疗PHH的效果，为PHH患者的治疗选择提供依据。
研究注册号
本研究于2020年6月17日在国际注册系统评价和荟萃分析方案平台上预先注册（INPLASY202060063）。
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