Lane G K, Oates R K
University of Sydney, Department of Paediatrics and Child Health, Children's Hospital, Camperdown, NSW.
Med J Aust. 1988 Feb 15;148(4):171-4.
Thirty-three cases of congenital syphilis that were seen at The Children's Hospital, Camperdown, over a 34-year period were reviewed. Twenty-nine cases were examples of early congenital syphilis, as the patients developed clinical features in the first two years of life, and the other four cases were examples of late congenital syphilis, with the clinical features developing between two years and nine months of age and 10 years of age. Twenty-five patients were symptomatic at the time of admission to hospital. The most common clinical feature on the patient's presentation to hospital was a maculopapular or vesiculobullous skin eruption which occurred in 13 of the infants. Hepatic and splenic enlargement were present in 12 cases, and nine children had the "snuffles". Five of the children died. Patient follow-up occurred in fewer than 40% of cases and three of the children who were followed-up suffer from developmental delay. Congenital syphilis can occur in all social groups but is most common in infants who are premature or are small for gestational age and are born to young, unmarried mothers of low socioeconomic status. The treatment of congenital syphilis is simple and effective although the patients may need to be linked with community-health facilities to assist in their compliance with follow-up appointments.
对34年间在坎珀当儿童医院就诊的33例先天性梅毒病例进行了回顾。29例为早期先天性梅毒，因为这些患者在出生后的头两年出现了临床症状，另外4例为晚期先天性梅毒，临床症状出现在2岁9个月至10岁之间。25例患者入院时出现症状。患儿入院时最常见的临床症状是13例婴儿出现的斑丘疹或水疱大疱性皮疹。12例出现肝脾肿大，9例儿童有“鼻塞”症状。5名儿童死亡。不到40%的病例进行了患者随访，在接受随访的儿童中有3例存在发育迟缓。先天性梅毒可发生于所有社会群体，但在早产或小于胎龄、母亲为社会经济地位低下的年轻未婚女性所生的婴儿中最为常见。先天性梅毒的治疗简单有效，尽管患者可能需要与社区卫生机构联系，以协助他们遵守随访预约。
