Tharmalingam Senthuran, Reddy Sanjay, Sharda Pankaj, Koch Christian A
Fox Chase Cancer Center, Philadelphia, USA.
Horm Metab Res. 2020 Sep;52(9):689-690. doi: 10.1055/a-1220-6971. Epub 2020 Aug 7.
Dear Editors,Hypocalcemia is not unusual in patients hospitalized for critical illness and has also been described after general surgery in addition to head and neck surgical procedures 1 2 3. Hypocalcemic events commonly occur in the setting of massive blood transfusion, albumin deficiency, vitamin D deficiency, and/or hypomagnesemia. In the absence of these factors, only slight decreases in calcium levels within the normal range have been reported during surgical procedures 1. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) causing asymptomatic hypocalcemia has only been reported in two previous studies 4 5. The etiology is unclear. We here report a patient who developed severe symptomatic hypocalcemia likely as a result of a profound inflammatory reaction with transient hypoparathyroidism after HIPEC.
低钙血症在因危重病住院的患者中并不罕见，除了头颈外科手术外，普通外科手术后也有相关报道[1-3]。低钙血症事件常见于大量输血、白蛋白缺乏、维生素D缺乏和/或低镁血症的情况下。在没有这些因素的情况下，手术过程中仅报告钙水平在正常范围内有轻微下降[1]。仅有两项先前的研究报道了减瘤手术联合热灌注化疗（HIPEC）导致无症状性低钙血症[4,5]。其病因尚不清楚。我们在此报告一例患者，其在HIPEC后可能因严重的炎症反应伴短暂性甲状旁腺功能减退而发生严重的症状性低钙血症。
