金属钴暴露与子代先天性心脏缺陷发生风险的关联：一项多医院病例对照研究。
Association between metal cobalt exposure and the risk of congenital heart defect occurrence in offspring: a multi-hospital case-control study.
作者信息
Zhang Nannan, Yang Shuihua, Yang Jiaxiang, Deng Ying, Li Shengli, Li Nana, Chen Xinlin, Yu Ping, Liu Zhen, Zhu Jun
机构信息
National Center for Birth Defect Monitoring, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, and State Key Laboratory of Biotherapy, Sichuan University, Sec. 3 No.17, South Ren Min Road, Chengdu, 610041, Sichuan, People's Republic of China.
Department of Ultrasound, Maternal and Child Healthcare Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, People's Republic of China.
出版信息
Environ Health Prev Med. 2020 Aug 8;25(1):38. doi: 10.1186/s12199-020-00877-2.
BACKGROUND
Many studies have investigated heavy metal exposure could increase the occurrence of congenital heart defects (CHDs). However, there are limited data regarding the relationship between cobalt exposure and CHD occurrence in offspring. The aim of this study was to analyze the association between cobalt exposure in mothers and the risk of CHDs in offspring.
MATERIALS AND METHODS
In order to explore the association between cobalt exposure and occurrence of congenital heart defect (CHD), a case-control study with 490 controls and 399 cases with CHDs in China were developed. The concentrations of cobalt in hair of pregnant woman and fetal placental tissue were measured and processed by a logistic regression analysis to explore the relationship between cobalt exposure and risk of CHDs.
RESULTS
The median concentration of hair cobalt in the control and case group was 0.023 ng/mg and 0.033 ng/mg (aOR, 1.837; 95% CI, 1.468-2.299; P < 0.001), respectively. And the median (5-95% range) fetal placental cobalt concentrations were 19.350 ng/g and 42.500 ng/g (aOR, 2.924; 95% CI, 2.211-3.868; P < 0.001) in the control and case groups, respectively. Significant differences in the middle level of cobalt in hair were found in the different CHD subtypes, including septal defects, conotruncal defects, right ventricular outflow tract obstruction, and left ventricular outflow tract obstruction (P < 0.001). Dramatically, different cobalt concentrations in fetal placental tissue were found in all subtypes of cases with CHDs (P < 0.01).
CONCLUSIONS
The finding suggested that the occurrence of CHDs may be associated with cobalt exposure.
背景
许多研究调查了重金属暴露会增加先天性心脏病（CHD）的发生率。然而，关于钴暴露与后代CHD发生之间关系的数据有限。本研究的目的是分析母亲钴暴露与后代CHD风险之间的关联。
材料与方法
为了探究钴暴露与先天性心脏病（CHD）发生之间的关联，在中国开展了一项病例对照研究，其中有490名对照者和399名CHD患者。测量了孕妇头发和胎儿胎盘组织中的钴浓度，并通过逻辑回归分析进行处理，以探究钴暴露与CHD风险之间的关系。
结果
对照组和病例组头发钴的中位数浓度分别为0.023 ng/mg和0.033 ng/mg（调整优势比，1.837；95%置信区间，1.468 - 2.299；P < 0.001）。对照组和病例组胎儿胎盘钴浓度的中位数（5 - 95%范围）分别为19.350 ng/g和42.500 ng/g（调整优势比，2.924；95%置信区间，2.211 - 3.868；P < 0.001）。在不同的CHD亚型中，包括房间隔缺损、圆锥动脉干畸形、右心室流出道梗阻和左心室流出道梗阻，头发中钴的中间水平存在显著差异（P < 0.001）。显著地，在所有CHD病例亚型的胎儿胎盘组织中发现了不同的钴浓度（P < 0.01）。
结论
该研究结果表明CHD的发生可能与钴暴露有关。
Zotero 插件