Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyangshi, Gyeonggi-do, Republic of Korea.
Research and Analysis Team, National Health Insurance Service Ilsan Hospital, Goyangshi, Gyeonggi-do, Republic of Korea.
Int J Infect Dis. 2020 Oct;99:266-268. doi: 10.1016/j.ijid.2020.08.001. Epub 2020 Aug 6.
To delineate clinical characteristics of asymptomatic and symptomatic patients confirmed with COVID-19 in South Korea.
Data were obtained from the Korean National Health Insurance Service database linked to the Korea Centers for Disease Control and Prevention data.
Among 10,237 patients (mean [SD] age, 45.0 [19.8] years; 60.1% female) who met the eligibility criteria for the study, 6,350 (62.0%) patients were asymptomatic, and 3,887(38.0%) patients were symptomatic. The mean and median age were similar between asymptomatic and symptomatic patients. Notably, we observed a U-shaped association between age group and the proportion of asymptomatic patients, with the nadir at 57.3% in the 40-49 age group. This U-shaped distribution was largely similar between men and women. The overall prevalence of asymptomatic individuals was higher, regardless of sex, residential area, income levels, and comorbid conditions.
In this national cohort of over 10,000 patients with COVID-19, more than 60% of all cases in South Korea reported no symptoms at the time of diagnosis. Expanding criteria for contact tracing and testing to capture potential transmission before symptom onset should be urgently considered to inform control strategies for COVID-19.
描述韩国确诊的 COVID-19 无症状和有症状患者的临床特征。
数据来自与韩国疾病控制与预防中心数据相关联的韩国国家健康保险服务数据库。
在符合研究条件的 10237 名患者（平均[标准差]年龄 45.0[19.8]岁；60.1%为女性）中，6350 名（62.0%）患者为无症状，3887 名（38.0%）患者为有症状。无症状和有症状患者的平均和中位年龄相似。值得注意的是，我们观察到年龄组与无症状患者比例之间存在 U 形关联，在 40-49 岁年龄组达到 57.3%的最低点。这种 U 形分布在男性和女性之间基本相似。无论性别、居住地区、收入水平和合并症如何，无症状个体的总体患病率均较高。
在这项针对超过 10000 名 COVID-19 患者的全国性队列研究中，韩国超过 60%的病例在诊断时没有症状。应紧急考虑扩大接触者追踪和检测的标准，以捕捉症状出现前的潜在传播，为 COVID-19 的控制策略提供信息。
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