Hwang Se Hwan, Gonzalez-Suarez Alan M, Stybayeva Gulnaz, Revzin Alexander
Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Department of Otolaryngology-Head and Neck Surgery, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Bucheon, Korea.
Clin Exp Otorhinolaryngol. 2021 Feb;14(1):29-42. doi: 10.21053/ceo.2020.00626. Epub 2020 Aug 11.
Microfluidic systems can be used to control picoliter to microliter volumes in ways not possible with other methods of fluid handling. In recent years, the field of microfluidics has grown rapidly, with microfluidic devices offering possibilities to impact biology and medicine. Microfluidic devices populated with human cells have the potential to mimic the physiological functions of tissues and organs in a three-dimensional microenvironment and enable the study of mechanisms of human diseases, drug discovery and the practice of personalized medicine. In the field of otorhinolaryngology, various types of microfluidic systems have already been introduced to study organ physiology, diagnose diseases, and evaluate therapeutic efficacy. Therefore, microfluidic technologies can be implemented at all levels of otorhinolaryngology. This review is intended to promote understanding of microfluidic properties and introduce the recent literature on application of microfluidic-related devices in the field of otorhinolaryngology.
微流控系统能够以其他流体处理方法无法实现的方式来控制皮升至微升体积的流体。近年来，微流控领域发展迅速，微流控设备为影响生物学和医学提供了可能性。搭载人类细胞的微流控设备有潜力在三维微环境中模拟组织和器官的生理功能，并有助于研究人类疾病机制、药物研发以及个性化医疗实践。在耳鼻咽喉科领域，已经引入了各种类型的微流控系统来研究器官生理学、诊断疾病以及评估治疗效果。因此，微流控技术可应用于耳鼻咽喉科的各个层面。本综述旨在增进对微流控特性的理解，并介绍微流控相关设备在耳鼻咽喉科领域应用的最新文献。
