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Oral ribavirin is a highly effective treatment for lower respiratory tract infections due to respiratory syncytial virus or parainfluenza after allogeneic stem cell transplantation.

作者信息

Stamouli Maria, Tsonis Ioannis, Gkirkas Konstantinos, Economopoulou Christina, Siafakas Nikolaos, Pournaras Spyridon, Antoniadou Anastasia, Chondropoulos Spyros, Karagiannidi Angeliki, Meletiadis Josef, Gigantes Stavros, Baltadakis Ioannis, Goussetis Evgenios, Karakasis Dimitrios, Tsirigotis Panagiotis

机构信息

Second Department of Internal Medicine, ATTIKO General University Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Department of Hematology and Bone Marrow Transplantation, Evangelismos General Hospital, Athens, Greece.

出版信息

Bone Marrow Transplant. 2021 Feb;56(2):511-513. doi: 10.1038/s41409-020-01022-x. Epub 2020 Aug 8.

DOI:10.1038/s41409-020-01022-x
PMID:32772044
Abstract
摘要

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1
Oral ribavirin is a highly effective treatment for lower respiratory tract infections due to respiratory syncytial virus or parainfluenza after allogeneic stem cell transplantation.口服利巴韦林是异基因干细胞移植后治疗由呼吸道合胞病毒或副流感病毒引起的下呼吸道感染的高效药物。
Bone Marrow Transplant. 2021 Feb;56(2):511-513. doi: 10.1038/s41409-020-01022-x. Epub 2020 Aug 8.
2
A risk-adapted approach to treating respiratory syncytial virus and human parainfluenza virus in allogeneic stem cell transplantation recipients with oral ribavirin therapy: A pilot study.采用风险适应性方法，对接受异基因干细胞移植的患者口服利巴韦林治疗呼吸道合胞病毒和人副流感病毒：一项试点研究。
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Respiratory syncytial virus and human metapneumovirus after allogeneic hematopoietic stem cell transplantation: Impact of the immunodeficiency scoring index, viral load, and ribavirin treatment on the outcomes.异基因造血干细胞移植后呼吸道合胞病毒和人偏肺病毒：免疫缺陷评分指数、病毒载量和利巴韦林治疗对结局的影响。
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4
Treatment stratification of respiratory syncytial virus infection in allogeneic stem cell transplantation.异基因造血干细胞移植后呼吸道合胞病毒感染的治疗分层。
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Oral Versus Aerosolized Ribavirin for the Treatment of Respiratory Syncytial Virus Infections in Hematopoietic Cell Transplant Recipients.口服与雾化利巴韦林治疗造血干细胞移植受者呼吸道合胞病毒感染。
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Oral ribavirin therapy for lower respiratory tract infection of respiratory syncytial virus complicating bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation.口服利巴韦林治疗异基因造血干细胞移植后呼吸道合胞病毒下呼吸道感染并发闭塞性细支气管炎
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Respiratory syncytial virus and parainfluenza virus infections in the immunocompromised host.免疫功能低下宿主中的呼吸道合胞病毒和副流感病毒感染
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Oral ribavirin for paramyxovirus infection after alemtuzumab-containing reduced-intensity conditioning HCT regimen.在含阿仑单抗的减低强度预处理造血干细胞移植方案后，口服利巴韦林治疗副粘病毒感染。
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Successful systemic high-dose ribavirin treatment of respiratory syncytial virus-induced infections occurring pre-engraftment in allogeneic hematopoietic stem cell transplant recipients.对异基因造血干细胞移植受者植入前发生的呼吸道合胞病毒感染进行成功的全身大剂量利巴韦林治疗。
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引用本文的文献

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The Combination of GS-441524 (Remdesivir) and Ribavirin Results in a Potent Antiviral Effect Against Human Parainfluenza Virus 3 Infection in Human Airway Epithelial Cell Cultures and in a Mouse Infection Model.GS-441524（瑞德西韦）与利巴韦林联合使用对人呼吸道上皮细胞培养物中的人副流感病毒3感染以及小鼠感染模型具有强效抗病毒作用。
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A robust mouse model of HPIV-3 infection and efficacy of GS-441524 against virus-induced lung pathology.一种稳定的 HPIV-3 感染小鼠模型和 GS-441524 对病毒诱导的肺部病变的疗效。
Nat Commun. 2024 Sep 5;15(1):7765. doi: 10.1038/s41467-024-52071-5.
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Occurrence of Central Nervous System Complications of Respiratory Syncytial Virus Infections: A Systematic Review with Meta-Analysis.
呼吸道合胞病毒感染的中枢神经系统并发症的发生情况：一项系统评价与荟萃分析
Epidemiologia (Basel). 2024 Jul 19;5(3):421-455. doi: 10.3390/epidemiologia5030031.
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Respiratory Syncytial Virus Infections in Recipients of Bone Marrow Transplants: A Systematic Review and Meta-Analysis.骨髓移植受者的呼吸道合胞病毒感染：一项系统评价与荟萃分析
Infect Dis Rep. 2024 Mar 29;16(2):317-355. doi: 10.3390/idr16020026.
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Outcome of Human Parainfluenza Virus infection in allogeneic stem cell transplantation recipients: possible impact of ribavirin therapy.异基因造血干细胞移植受者人副流感病毒感染的转归：利巴韦林治疗的可能影响。
Infection. 2024 Oct;52(5):1941-1952. doi: 10.1007/s15010-024-02213-0. Epub 2024 Apr 24.
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Approach to hematopoietic cell transplant candidates with respiratory viral detection.对检测到呼吸道病毒的造血细胞移植候选者的处理方法
Front Pediatr. 2024 Jan 18;11:1339239. doi: 10.3389/fped.2023.1339239. eCollection 2023.