Sundelin J, Björck L, Lögdberg L
Department of Cell Research, Wallenberg Laboratory, University of Uppsala, Sweden.
Scand J Immunol. 1988 Feb;27(2):195-9. doi: 10.1111/j.1365-3083.1988.tb02339.x.
The primary structure of rat beta 2-microglobulin (beta 2m) was determined. It is a polypeptide of 99 amino acids with the following sequence: IQKTPQIQVY SRHPPENGKP NFLNCYVSQF HPPQIEIELL KNGKKIPNIE MSDLSFSKDW SFYILAHTEF TPTETDVYAC RVKHVTLKEP KTVTWDRDM. The primary structure was determined by NH2-terminal sequence analysis together with sequence determination of one cyanogen bromide fragment and one tryptic peptide. Of other known beta 2m sequences, rat beta 2m is most homologous to mouse beta 2m (83% identity). The rabbit, human, and guinea pig sequences are more distant, with 24, 27, and 31% differences, respectively.
已确定大鼠β2-微球蛋白（β2m）的一级结构。它是一种由99个氨基酸组成的多肽，序列如下：IQKTPQIQVY SRHPPENGKP NFLNCYVSQF HPPQIEIELL KNGKKIPNIE MSDLSFSKDW SFYILAHTEF TPTETDVYAC RVKHVTLKEP KTVTWDRDM。一级结构通过氨基末端序列分析以及一个溴化氰片段和一个胰蛋白酶肽段的序列测定来确定。在其他已知的β2m序列中，大鼠β2m与小鼠β2m的同源性最高（同一性为83%）。兔、人和豚鼠的序列差异更大，分别有24%、27%和31%的差异。
