Akula Shaw M, Abrams Stephen L, Steelman Linda S, Candido Saverio, Libra Massimo, Lerpiriyapong Kvin, Cocco Lucio, Ramazzotti Giulia, Ratti Stefano, Follo Matilde Y, Martelli Alberto M, Blalock William L, Piazzi Manuela, Montalto Giuseppe, Cervello Melchiorre, Notarbartolo Monica, Basecke Jorg, McCubrey James A
Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, 27858, USA.
Department of Biomedical and Biotechnological Sciences-Oncological, Clinical and General Pathology Section, University of Catania, Catania, Italy; Research Center for Prevention, Diagnosis and Treatment of Cancer (PreDiCT), University of Catania, Catania, Italy.
Adv Biol Regul. 2020 Aug;77:100739. doi: 10.1016/j.jbior.2020.100739. Epub 2020 Jun 26.
The COVID-19 pandemic has put a serious strain on health treatments as well at the economies of many nations. Unfortunately, there is not currently available vaccine for SARS-Cov-2/COVID-19. Various types of patients have delayed treatment or even routine check-ups and we are adapting to a virtual world. In many cases, surgeries are delayed unless they are essential. This is also true with regards to cancer treatments and screening. Interestingly, some existing drugs and nutraceuticals have been screened for their effects on COVID-19. Certain FDA approved drugs, vitamin, natural products and trace minerals may be repurposed to treat or improve the prevention of COVID-19 infections and disease progression. This review article will summarize how the treatments of various cancer patients has changed during the COVID-19 era as well as discuss the promise of some existing drugs and other agents to be repurposed to treat this disease.
新冠疫情给许多国家的医疗保健以及经济都带来了沉重压力。不幸的是，目前尚无针对严重急性呼吸综合征冠状病毒2/新冠病毒病（SARS-CoV-2/COVID-19）的疫苗。各类患者的治疗甚至常规检查都被推迟，我们正在适应一个虚拟世界。在许多情况下，手术会被推迟，除非是必要手术。癌症治疗和筛查也是如此。有趣的是，一些现有药物和营养保健品已针对其对新冠病毒病的作用进行了筛选。某些美国食品药品监督管理局（FDA）批准的药物、维生素、天然产物和微量矿物质可能会被重新用于治疗或改善对新冠病毒病感染及疾病进展的预防。这篇综述文章将总结在新冠病毒病流行时期各类癌症患者的治疗发生了哪些变化，并讨论一些现有药物和其他制剂有望被重新用于治疗该疾病的前景。
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