Koyle M A, Ward H J, Twomey P A, Glassock R J, Rajfer J
Department of Surgery/Urology, Harbor/UCLA Medical Center, Torrance.
Urology. 1988 Feb;31(2):103-6. doi: 10.1016/0090-4295(88)90028-3.
Over a five-year period 100 cadaveric renal transplants were performed. In 91 of these recipients, a prophylactic parenteral antibiotic (cefoperazone) was administered and closed wound drainage was used. Of these 91 patients, 33 received azathioprine/prednisone immunosuppression, whereas cyclosporine/prednisone with or without azathioprine was used in the remaining 58. The incidence of wound infections was significantly reduced from 12 per cent (4/33) in the azathioprine group to 1.7 per cent (1/58) in the cyclosporine group (p less than 0.01). When conventional immunosuppression (azathioprine/prednisone) is employed in renal transplantation, triple antibiotic prophylaxis that includes an aminoglycoside is most effective in preventing wound infections. A single non-nephrotoxic antibiotic, cefoperazone, offers similar protection in the cyclosporine/prednisone-treated renal transplant recipient.
在五年期间共进行了100例尸体肾移植手术。其中91例受者接受了预防性非肠道抗生素（头孢哌酮）治疗，并采用了伤口闭式引流。在这91例患者中，33例接受硫唑嘌呤/泼尼松免疫抑制治疗，其余58例使用环孢素/泼尼松，部分联合硫唑嘌呤。伤口感染发生率从硫唑嘌呤组的12%（4/33）显著降低至环孢素组的1.7%（1/58）（p<0.01）。在肾移植中采用传统免疫抑制（硫唑嘌呤/泼尼松）时，包含氨基糖苷类的三联抗生素预防对预防伤口感染最为有效。单一的非肾毒性抗生素头孢哌酮，对接受环孢素/泼尼松治疗的肾移植受者也有类似的保护作用。
