Department of Intensive Care Unit, Lanzhou University Second Hospital, Lanzhou, Gansu, China.
J Chin Med Assoc. 2020 Nov;83(11):1004-1007. doi: 10.1097/JCMA.0000000000000404.
To explore the potential role of the platelet/lymphocyte ratio (PLR) as a prognostic marker in septic patients with acute kidney injury (AKI) and to provide theoretical evidence for the epidemiological study of the prognosis of patients with septic AKI in its early stage.
A pilot study was conducted. A logistic regression analysis was conducted to screen the risk factors, and the selected factors were performed using multiple logistic regression analysis; a Receiver Operating Characteristic curve was used to determine the optimal cutoff value of the PLR and then to calculate the sensitivity and specificity of the PLR ratio.
Mechanical ventilation, platelet count, PLR, and arterial blood lactate concentration have a correlation with sepsis (p < 0.05). An elevated PLR is significantly associated with a worse prognosis of sepsis-induced AKI (higher mortality).
The PLR might be an effective factor in predicting a worse prognosis of septic AKI patients.
探讨血小板/淋巴细胞比值（PLR）在合并急性肾损伤（AKI）的脓毒症患者中的预后价值，为脓毒症 AKI 早期患者的预后进行流行病学研究提供理论依据。
采用前瞻性队列研究。采用 logistic 回归分析筛选危险因素，将有意义的因素进行多因素 logistic 回归分析；采用受试者工作特征曲线（ROC 曲线）确定 PLR 的最佳截断值，然后计算 PLR 比值的灵敏度和特异度。
机械通气、血小板计数、PLR、动脉血乳酸浓度与脓毒症相关（p<0.05）。高 PLR 与脓毒症诱导的 AKI 预后不良（死亡率更高）显著相关。
PLR 可能是预测脓毒症 AKI 患者预后不良的有效因素。
