Department of Orthopaedic Surgery, Loma Linda University, Loma Linda, California.
JBJS Case Connect. 2020 Jul-Sep;10(3):e19.00636. doi: 10.2106/JBJS.CC.19.00636.
A 32-year-old man developed lumbar discitis and osteomyelitis after receiving a cell-based injection for the treatment of degenerative disc disease. Initial cultures were negative, but he continued to worsen, and a repeat set of cultures was taken. On day 10, Cutibacterium acnes was isolated. He was then successfully treated with 12 weeks of intravenous antibiotics.
There is minimal regulation on the preparation or administration of cell-based interventions. It is important to consider slow growing organisms such as C. acnes in patients presenting with spinal infection with insidious onset after these treatments.
一名 32 岁男性因退行性椎间盘疾病接受细胞注射治疗后出现腰椎间盘炎和骨髓炎。初始培养结果为阴性，但他的病情持续恶化，再次进行了一组培养。第 10 天，分离出痤疮丙酸杆菌。随后他成功接受了 12 周的静脉抗生素治疗。
细胞干预措施的制备或给药几乎没有受到监管。对于这些治疗后出现隐匿性发病的脊柱感染患者，应考虑缓慢生长的生物体，如痤疮丙酸杆菌。
