Woods Mary, Ruddell Shannon, Sandsund Cathy, Thomas Karen, Shaw Clare
Lymphoedema Service, The Royal Marsden National Health Service Foundation Trust, Chelsea, London, United Kingdom.
J Gynecol Surg. 2020 Aug 1;36(4):198-204. doi: 10.1089/gyn.2020.0008. Epub 2020 Jul 28.
Patients at risk of lymphedema following pelvic lymph-node dissection for gynecologic cancers (PLND) often receive prophylactic risk-reducing advice and compression stockings to wear for 6 months, without clear supportive evidence or evaluation of the impact. This study explored if these measures affected lymphedema development 1 year after PLND. Relevant data of patients who had undergone PLND over a 10-year period were allocated into 2 groups: Group A had data on patients who received prophylactic lymphedema risk-reduction advice and compression stockings for to wear for 6 months. Group B had data on patients who did not receive prophylactic lymphedema risk-reduction advice or prophylactic compression stockings. Exclusion criteria were preexisting swelling, medication that increased edema, symptom management during end-of-life care. Data were analyzed for statistical significance between the groups. Of 108 patients, 19/60 patients (35%) in Group A and 6/48 (12.5%) patients in Group B developed lymphedema. There was no statistical difference between the groups for the presence of lymphedema. This study did not show that prophylactic compression stockings reduced the development of lymphedema but suggested an increased awareness of the signs and symptoms of lymphedema among patients who received risk-reducing education and the compression garments. These results should be tested in a prospective, controlled trial, and suggest that a change in current clinical practice is appropriate. (J GYNECOL SURG 36:198).
因妇科癌症接受盆腔淋巴结清扫术(PLND)后有发生淋巴水肿风险的患者,通常会收到预防性降低风险的建议,并被要求穿戴弹力袜6个月,但缺乏明确的支持证据或对其影响的评估。本研究探讨了这些措施在PLND术后1年是否会影响淋巴水肿的发生。将10年间接受PLND的患者的相关数据分为两组:A组为接受预防性淋巴水肿风险降低建议并穿戴弹力袜6个月的患者的数据。B组为未接受预防性淋巴水肿风险降低建议或预防性弹力袜的患者的数据。排除标准为既往存在肿胀、增加水肿的药物治疗、临终关怀期间的症状管理。对两组间的数据进行统计学意义分析。108例患者中,A组19/60例患者(35%)发生淋巴水肿,B组6/48例患者(12.5%)发生淋巴水肿。两组间淋巴水肿的存在无统计学差异。本研究未表明预防性弹力袜可降低淋巴水肿的发生,但提示接受风险降低教育并穿戴弹力袜的患者对淋巴水肿体征和症状的认识有所提高。这些结果应在前瞻性对照试验中进行验证,并表明改变当前临床实践是合适的。(《妇科手术学杂志》36:198)