Werning C, Weitz T, Ludwig B
St. Katharinen Hospital, Frechen bei Koeln, West Germany.
Am J Med. 1988 Jan 29;84(1B):104-8.
One hundred forty-nine patients between 56 and 80 years of age with mild to moderate hypertension received indapamide (2.5 mg per day) monotherapy for 12 weeks. In addition to studies of the efficacy and tolerance of indapamide, the study comprised an assessment of well-being, which was carried out objectively by the physician, and subjectively by the patient himself, by means of a list of complaints and a visual analogue scale. The mean blood pressure was lowered from 179/91 mm Hg (supine) before treatment to 149/81 mm Hg at the end of the treatment. The general well-being of the patients, as judged by the physician, showed a markedly positive evolution. The patients themselves indicated that their most frequent symptoms, such as sleep disorders, functional organic disturbances, and sensory and motor fatigue, had improved by 65 to 85 percent, indicating a tendency to better compliance.
149名年龄在56至80岁之间的轻度至中度高血压患者接受了吲达帕胺（每日2.5毫克）单药治疗，为期12周。除了对吲达帕胺的疗效和耐受性进行研究外，该研究还包括对幸福感的评估，评估由医生客观进行，并由患者本人通过一份症状清单和视觉模拟量表主观进行。平均血压从治疗前仰卧位的179/91毫米汞柱降至治疗结束时的149/81毫米汞柱。根据医生的判断，患者的总体幸福感呈现出明显的积极变化。患者自己表示，他们最常见的症状，如睡眠障碍、功能性器官紊乱以及感觉和运动疲劳，已经改善了65%至85%，表明有更好的依从性倾向。
