Dyal R, Crankshaw D J
Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada.
Am J Obstet Gynecol. 1988 Feb;158(2):281-5. doi: 10.1016/0002-9378(88)90138-x.
We have investigated the ability of three synthetic prostanoids to directly influence uterine contractility by studying the effects in vitro. Strips of lower uterine segment smooth muscle were obtained from women undergoing elective cesarean section at term. The ability of these strips to develop tension in the presence of cumulative additions of prostanoids or oxytocin was assessed. Spontaneous contractions were inhibited by ZK 96.480, a stable synthetic analog of prostaglandin I2, with a 50th percentile effective concentration (EC50) of 8 nmol/L. Both sulprostone, an analog with selectivity for some of the actions of prostaglandin E2, and U-44069, a stable thromboxane A2 mimetic, caused excitation with EC50s of 20 and 16 nmol/L, respectively. The EC50 for oxytocin was 6 nmol/L. There were no significant differences in the maximal tensions developed in response to the excitatory prostanoids or oxytocin.
我们通过体外研究，考察了三种合成类前列腺素直接影响子宫收缩力的能力。取自足月择期剖宫产女性的子宫下段平滑肌条。评估了这些肌条在累积添加类前列腺素或缩宫素时产生张力的能力。稳定的前列腺素I2合成类似物ZK 96.480可抑制自发收缩，其第50百分位数有效浓度（EC50）为8 nmol/L。对前列腺素E2某些作用具有选择性的类似物舒前列素和稳定的血栓素A2模拟物U-44069均可引起兴奋，其EC50分别为20 nmol/L和16 nmol/L。缩宫素的EC50为6 nmol/L。对兴奋性类前列腺素或缩宫素产生的最大张力无显著差异。
