Cook M, Molto E, Anderson C
Department of Pathology, University Hospital/University of Western Ontario, London, Canada.
Am J Phys Anthropol. 1988 Jan;75(1):23-30. doi: 10.1002/ajpa.1330750104.
A histomorphometric study of thin femoral head sections of a skeletal sample from the Dakhleh Oasis, Egypt, dated from circa 36 B.C. to 400 A.D., identified an adult female (Dk31-A1) in her mid-50s with a high percentage resorption surface with tunneling resorption as is typically found in hyperparathyroidism. Five static histomorphometric bone parameters were measured with the following results for this individual: 1) mean wall thickness, 41.94 micron, 2) trabecular bone volume, 18.54%, 3) surface volume, 4,070 mm2/cm3, 4) mean trabecular diameter, 132 microns, and 5) total resorption surface, 12.31%. The overall histomorphometric features and differential diagnosis support the diagnosis of hyperparathyroidism. We conclude that histomorphometry of dried bone, particularly in this case where preservation is ideal, is a valuable investigative technique for paleopathology.
对来自埃及达赫拉绿洲、年代约为公元前36年至公元400年的一具骨骼样本的股骨头薄片进行的组织形态计量学研究，确定了一名50多岁的成年女性（Dk31-A1），其具有高比例的吸收表面，并伴有穿凿样吸收，这是甲状旁腺功能亢进症的典型表现。对该个体测量了五个静态组织形态计量学骨参数，结果如下：1）平均壁厚度，41.94微米；2）小梁骨体积，18.54%；3）表面体积，4,070平方毫米/立方厘米；4）平均小梁直径，132微米；5）总吸收表面，12.31%。整体组织形态计量学特征和鉴别诊断支持甲状旁腺功能亢进症的诊断。我们得出结论，干骨的组织形态计量学，特别是在保存理想的这种情况下，是古病理学中一种有价值的研究技术。
