Chen Yufei, Zhong Haoxuan, Zhao Yikai, Luo Xinping, Gao Wen
Department of Cardiology, Huashan Hospital, Fudan University, No.12 Middle Wulumuqi Road, Jing'an District, Shanghai, 200040 China.
Biomark Res. 2020 Aug 2;8:28. doi: 10.1186/s40364-020-00207-2. eCollection 2020.
Beyond hemostasis, thrombosis and wound healing, it is becoming increasingly clear that platelets play an integral role in inflammatory response and immune regulation. Platelets recognize pathogenic microorganisms and secrete various immunoregulatory cytokines and chemokines, thus facilitating a variety of immune effects and regulatory functions. In this review, we discuss recent advances in signaling of platelet activation-related biomarkers in inflammatory settings and application prospects to apply for disease diagnosis and treatment.
除了止血、血栓形成和伤口愈合外，越来越清楚的是血小板在炎症反应和免疫调节中起着不可或缺的作用。血小板识别致病微生物并分泌各种免疫调节细胞因子和趋化因子，从而促进多种免疫效应和调节功能。在本综述中，我们讨论了炎症环境中血小板活化相关生物标志物信号传导的最新进展以及其在疾病诊断和治疗中的应用前景。
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