Sorensen F H
Acta Pathol Microbiol Scand A. 1977 May;85(3):367-72.
A quantitative examination including total and differential counts of nuclei and determination of total glomerular and mesangial areas was carried out in a consecutive series of biopsies from 14 patients with acute renal allograft rejections. The biopsies included in the study were taken within 4--30 days after transplantation because of suspected acute rejection, and histological examination revealed interstitial and vascular signs of rejection without the presence of cortical infarcts. Mesangial area per cent of total area was found to be significantly higher in allografts than in control kidneys, just as a statistically significant increase in the number of mesangial nuclei was demonstrated. Three of the 14 allografts had to be rechanges in these 3 biopsies were more pronounced than those in the remaining biopsies. It is suggested that quantitative glomerular studies might yield data of significance for prediction of the ultimate fate of the graft.
对14例急性肾移植排斥反应患者的连续系列活检组织进行了定量检查，包括细胞核的总数和分类计数以及肾小球和系膜总面积的测定。本研究纳入的活检组织是在移植后4至30天内，因怀疑急性排斥反应而获取的，组织学检查显示有排斥反应的间质和血管征象，但无皮质梗死。发现同种异体移植肾的系膜面积占总面积的百分比显著高于对照肾，系膜细胞核数量也有统计学意义的增加。14例同种异体移植肾中有3例不得不再次活检，这3例活检中的变化比其余活检更为明显。有人提出，肾小球定量研究可能会得出对预测移植肾最终转归具有重要意义的数据。
